Daily Summer Temperatures and Hospitalization for Acute Cardiovascular Events: Impact of Outdoor PM 2.5 Oxidative Potential on Observed Associations Across Canada.
Journal
Epidemiology (Cambridge, Mass.)
ISSN: 1531-5487
Titre abrégé: Epidemiology
Pays: United States
ID NLM: 9009644
Informations de publication
Date de publication:
01 11 2023
01 11 2023
Historique:
medline:
29
9
2023
pubmed:
21
9
2023
entrez:
21
9
2023
Statut:
ppublish
Résumé
Oxidative stress plays an important role in the health impacts of both outdoor fine particulate air pollution (PM 2.5 ) and thermal stress. However, it is not clear how the oxidative potential of PM 2.5 may influence the acute cardiovascular effects of temperature. We conducted a case-crossover study of hospitalization for cardiovascular events in 35 cities across Canada during the summer months (July-September) between 2016 and 2018. We collected three different metrics of PM 2.5 oxidative potential each month in each location. We estimated associations between lag-0 daily temperature (per 5ºC) and hospitalization for all cardiovascular (n = 44,876) and ischemic heart disease (n = 14,034) events across strata of monthly PM 2.5 oxidative potential using conditional logistical models adjusting for potential time-varying confounders. Overall, associations between lag-0 temperature and acute cardiovascular events tended to be stronger when outdoor PM 2.5 oxidative potential was higher. For example, when glutathione-related oxidative potential (OP GSH ) was in the highest tertile, the odds ratio (OR) for all cardiovascular events was 1.040 (95% confidence intervals [CI] = 1.004, 1.074) compared with 0.980 (95% CI = 0.943, 1.018) when OP GSH was in the lowest tertile. We observed a greater difference for ischemic heart disease events, particularly for older subjects (age >70 years). The acute cardiovascular health impacts of summer temperature variations may be greater when outdoor PM 2.5 oxidative potential is elevated. This may be particularly important for ischemic heart disease events.
Sections du résumé
BACKGROUND
Oxidative stress plays an important role in the health impacts of both outdoor fine particulate air pollution (PM 2.5 ) and thermal stress. However, it is not clear how the oxidative potential of PM 2.5 may influence the acute cardiovascular effects of temperature.
METHODS
We conducted a case-crossover study of hospitalization for cardiovascular events in 35 cities across Canada during the summer months (July-September) between 2016 and 2018. We collected three different metrics of PM 2.5 oxidative potential each month in each location. We estimated associations between lag-0 daily temperature (per 5ºC) and hospitalization for all cardiovascular (n = 44,876) and ischemic heart disease (n = 14,034) events across strata of monthly PM 2.5 oxidative potential using conditional logistical models adjusting for potential time-varying confounders.
RESULTS
Overall, associations between lag-0 temperature and acute cardiovascular events tended to be stronger when outdoor PM 2.5 oxidative potential was higher. For example, when glutathione-related oxidative potential (OP GSH ) was in the highest tertile, the odds ratio (OR) for all cardiovascular events was 1.040 (95% confidence intervals [CI] = 1.004, 1.074) compared with 0.980 (95% CI = 0.943, 1.018) when OP GSH was in the lowest tertile. We observed a greater difference for ischemic heart disease events, particularly for older subjects (age >70 years).
CONCLUSIONS
The acute cardiovascular health impacts of summer temperature variations may be greater when outdoor PM 2.5 oxidative potential is elevated. This may be particularly important for ischemic heart disease events.
Identifiants
pubmed: 37732880
doi: 10.1097/EDE.0000000000001651
pii: 00001648-990000000-00176
doi:
Substances chimiques
Dust
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
897-905Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest.
Références
Khraishah H, Alahmad B, Ostergard RL Jr, et al. Climate change and cardiovascular disease: implications for global health. Nat Rev Cardiol. 2022;19:798–812.
Rajagopalan S, Al-Kindi SG, Brook RD. Air pollution and cardiovascular disease: JACC state-of-the-art review. JACC. 2018;72:2054–2070.
Liu J, Varghese B, Hansen A, et al. Heat exposure and cardiovascular health outcomes: a systematic review and meta-analysis. Lancet Planet Health. 2022;6:e484–e495.
Slimen IB, Najar T, Ghram A, Dabbebi H, Mrad MB, Abdrabbah M. Reactive oxygen species, heat stress, and oxidative-induced mitochondrial damage. A review. Int J Hyperthermia. 2014;30:513–523.
Gao D, Ripley S, Weichenthal S, Godri Pollitt KJ. Ambient particulate matter oxidative potential: chemical determinants, associated health effects, and strategies for risk management. Free Radic Biol Med. 2020;151:7–25.
Quindry J, Miller L, McGinnis G, et al. Environmental temperature and exercise-induced blood oxidative stress. Int J Sport Nutr Excerc Metab. 2013;23:128–136.
Weichenthal S, Lavigne E, Traub A, et al. Association of sulfur, transition metals, and the oxidative potential of outdoor PM 2.5 with acute cardiovascular events: a case–crossover study of Canadian adults. Environ Health Perspect. 2021;129:107005.
Rahman MM, McConnel R, Schlaerth H, et al. The effects of co-exposure to extremes of heat and particulate air pollution on mortality in California: implications for climate change. Am J Respir Crit Care Med. 2022;206:1117–1127.
Rai M, Stafoggia M, de’Donato F, et al. Heat-related cardiorespiratory mortality: effect modification by air pollution across 482 cities from 24 countries. Environ Int. 2023;174:107825.
Anenberg SC, Haines S, Wang E, Nassikas N, Kinney PL. Synergistic health effects of air pollution, temperature, and pollen exposure: a systematic review of epidemiological evidence. Environ Health. 2020;19:130.
Janes H, Sheppard L, Lumley T. Case–crossover analyses of air pollution exposure data: referent selection strategies and their implications for bias. Epidemiol. 2005;16:717–726.
Alahmad B, Khraishah H, Roye D, et al. Associations between extreme temperatures and cardiovascular cause-specific mortality: results from 27 countries. Circulation. 2023;147:35–46.
Gibson D, Richards H, Chapman A. The national ambulatory care reporting system: factors that affect the quality of its emergency data. . Int J Information Quality. 2008;2:97–114.
Ministère de la Santé et des Services Sociaux. MED-ÉCHO–Hospitalisations et chirurgies d’un jour dans les centres hospitaliers du Québec. Ministère de la Santé et des Services sociaux. 2021. Available at: https://www.msss.gouv.qc.ca/professionnels/statistiques-donnees-services-sante-services-sociaux/med-echo-hospitalisations-et-chirurgies-d-un-jour-dans-les-centres-hospitaliers-du-quebec/ . Accessed 11 April 2022.
Weichenthal S, Lavigne E, Evans G, Pollitt K, Burnett RT. Ambient PM 2.5 and risk of emergency room visits for myocardial infarction: impact of regional PM 2.5 oxidative potential: a case–crossover study. Environ Health. 2016;15:15.
Maikawa CL, Weichenthal S, Wheeler AJ, et al. Particulate oxidative burden as a predictor of exhaled nitric oxide in children with asthma. Environ Health Perspect. 2016;124:1616–1622.
Baker MA, Cerniglia GJ, Zaman A. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal Biochem. 1990;190:360–365.
Godri KJ, Green DC, Fuller GW, et al. Particulate oxidative burden associated with firework activity. Environ Sci Technol. 2010;44:8295–8301.
Griffith OW. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-Vinylpyridine. Anal Biochem. 1980;106:207–212.
Mudway IS, Stenfors N, Duggan ST, et al. An in vitro and in vivo investigation of the effects of diesel exhaust on human airway lining fluid antioxidants. Arch Biochem Biophys. 2004;423:200–212.
Cho AK, Sioutas C, Miguel AH, et al. Redox activity of airborne particulate matter at different sites in the Los Angeles Basin. Environ Res. 2005;99:40–47.
Pio CA, Legrand M, Alves CA, et al. Chemical composition of atmospheric aerosols during the 2003 summer intense forest fire period. Atmos Environ. 2008;42:7530–7543.
Phung D, Thai PK, Guo Y, Morawska L, Rutherford S, Chu C. Ambient temperature and risk of cardiovascular hospitalization: an updated systematic review and meta-analysis. Sci Total Environ. 2016;550:1084–1102.
Cicci KR, Maltby A, Clemens KK, et al. High temperatures and cardiovascular-related morbidity: a scoping review. In J Environ Res Public Health. 2022;19:11243.
Bayentin L, El Adlouni S, Ouarda TBMJ, Gosselin P, Doyon B, Cheban F. Spatial variability of climate effects on ischemic heart disease hospitalization rates for the period 1989-2006 in Quebec, Canada. In J Health Geogr. 2010;9:5.
Gifford RM, Todisco T, Stacey M, et al. Risk of heat illness in men and women: a systematic review and meta-analysis. Environ Res. 2019;171:24–35.
Statistics Canada, Environment, Energy and Transportation Statistics Division. Release date: 2021-10-19. Available: https://www150.statcan.gc.ca/t1/tbl1/en/tv.action?pid=3810001901&pickMembers%5B0%5D=1.2&cubeTimeFrame.startYear=2017&cubeTimeFrame.endYear=2019&referencePeriods=20170101%2C20190101 . Accessed December 15, 2022.
Peltier RE, Hsu SI, Lall R, Lippmann M. Residual oil combustion: a major source of airborne nickel in New York City. J Expo Sci Environ Epidemiol. 2009;19:603–612.
Dong S, Ochoa Gonzalez R, Harrison RM, et al. Isotopic signatures suggest important contributions from recycled gasoline, road dust and non-exhaust traffic sources for copper, zinc and lead in PM10 in London, United Kingdom. Atmos Environ. 2017;165:88–98.
Naranjan D, Rana T, Thomas N. Role of oxidative stress in cardiovascular diseases. J Hypertens. 2000;18:655–673.