A Comprehensive Wavefront Assessment of Keratoconus Using an Integrated Scheimpflug Corneal Tomographer/Hartmann-Shack Wavefront Aberrometer.
Journal
Eye & contact lens
ISSN: 1542-233X
Titre abrégé: Eye Contact Lens
Pays: United States
ID NLM: 101160941
Informations de publication
Date de publication:
21 Sep 2023
21 Sep 2023
Historique:
accepted:
19
08
2023
medline:
21
9
2023
pubmed:
21
9
2023
entrez:
21
9
2023
Statut:
aheadofprint
Résumé
To characterize higher-order aberrations (HOAs) in different severities of keratoconus (KC) from the anterior and posterior corneal surfaces and whole eye using an integrated Scheimpflug corneal tomographer/Hartmann-Shack wavefront aberrometer. This study included eyes with clinical KC, topographic KC (no clinical signs), fellow eyes with very asymmetric ectasia with normal topography and no clinical signs (VAE-NT), and control eyes. Corneal and ocular wavefront aberrations were obtained using an integrated Scheimpflug tomographer/Hartmann-Shack wavefront aberrometer. The diagnostic capability of distinguishing VAE-NT from the control was also tested. This study included 68 eyes with clinical KC, 44 with topographic KC, 26 with VAE-NT, and 45 controls. Clinical KC had significantly greater total HOAs and coma from the anterior and posterior corneal surfaces and whole eye than the other groups (P<0.05). Although topographic KC had significantly greater values in all wavefront parameters than the control (P<0.05), ocular and corneal HOAs did not differ between the VAE-NT and control groups. The coma from the anterior cornea in topographic KC was significantly greater than that in VAE-NT (P<0.05); the coma from the posterior cornea and whole eye did not differ. Total HOAs from the anterior corneal surface exhibited the highest area under the receiver operating characteristic curve value of 0.774 (sensitivity, 73%; specificity, 78%). A comprehensive wavefront assessment can be used to quantitatively evaluate corneal and ocular HOAs across various severity of KC. Total HOAs from the anterior corneal surface exhibited the potential ability in distinguishing VAE-NT from the control eyes.
Identifiants
pubmed: 37732884
doi: 10.1097/ICL.0000000000001041
pii: 00140068-990000000-00146
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : SEED
ID : NA
Informations de copyright
Copyright © 2023 Contact Lens Association of Ophthalmologists.
Références
Liang J, Grimm B, Goelz S, et al. Objective measurement of wave aberrations of the human eye with the use of a Hartmann-Shack wave-front sensor. J Opt Soc Am A Opt Image Sci Vis 1994;11:1949–1957.
Maeda N. Clinical applications of wavefront aberrometry—a review. Clin Exp Ophthalmol 2009;37:118–129.
Visser N, Berendschot TTJM, Verbakel F, et al. Evaluation of the comparability and repeatability of four wavefront aberrometers. Invest Ophthalmol Vis Sci 2011;52:1302–1311.
Santodomingo-Rubido J, Carracedo G, Suzaki A, et al. Keratoconus: An updated review. Cont Lens Anterior Eye 2022;45:101559.
Maeda N, Fujikado T, Kuroda T, et al. Wavefront aberrations measured with Hartmann-Shack sensor in patients with keratoconus. Ophthalmology 2002;109:1996–2003.
Kosaki R, Maeda N, Bessho K, et al. Magnitude and orientation of Zernike terms in patients with keratoconus. Invest Ophthalmol Vis Sci 2007;48:3062–3068.
Piñero DP, Alió JL, Alesón A, et al. Pentacam posterior and anterior corneal aberrations in normal and keratoconic eyes. Clin Exp Optom 2009;92:297–303.
Chen M, Yoon G. Posterior corneal aberrations and their compensation effects on anterior corneal aberrations in keratoconic eyes. Invest Ophthalmol Vis Sci 2008;49:5645–5652.
Nakagawa T, Maeda N, Kosaki R, et al. Higher-order aberrations due to the posterior corneal surface in patients with keratoconus. Invest Ophthalmol Vis Sci 2009;50:2660–2665.
Gomes JAP, Tan D, Rapuano CJ, et al. Global consensus on keratoconus and ectatic diseases. Cornea 2015;34:359–369.
Randleman JB, Dupps WJ Jr, Santhiago MR, et al. Screening for keratoconus and related ectatic corneal disorders. Cornea 2015;34:e20–e22.
Saad A, Gatinel D. Screening for keratoconus: Lack of a scientific base regarding the global consensus? Cornea 2015;34:e33–e35.
Klyce SD. Chasing the suspect: Keratoconus. Br J Ophthalmol 2009;93:845–847.
Henriquez MA, Hadid M, Izquierdo L Jr. A systematic review of subclinical keratoconus and forme fruste keratoconus. J Refract Surg 2020;36:270–279.
Koh S, Inoue R, Maeno S, et al. Characteristics of higher-order aberrations in different stages of keratoconus. Eye Contact Lens 2022;48:256–260.
Maeno S, Koh S, Inoue R, et al. Fourier analysis on irregular corneal astigmatism using optical coherence tomography in various severity stages of keratoconus. Am J Ophthalmol 2022;243:55–65.
Rabinowitz YS. Keratoconus. Surv Ophthalmol 1998;42:297–319.
McAlinden C, Khadka J, Pesudovs K. Precision (repeatability and reproducibility) studies and sample-size calculation. J Cataract Refract Surg 2015;41:2598–2604.
Shetty R, Trivedi D, Ranade R, et al. Repeatability and agreement of wavefront aberrations of a new hybrid topographer and aberrometer in healthy eyes. J Cataract Refract Surg 2022;48:408–416.
Kundu G, Shetty R, Khamar P, et al. Impact of tear optics on the repeatability of Pentacam AXL wave and iTrace in measuring anterior segment parameters and aberrations. Indian J Ophthalmol 2022;70:1150–1157.
Kundu G, Shetty R, Ranade R, et al. Repeatability and agreement of a new Scheimpflug device and a Hartmann-Shack aberrometer with a ray-tracing aberrometer in normal, keratoconus, and CXL groups. J Refract Surg 2022;38:201–208.
Wan KH, Liao XL, Yu M, et al. Wavefront aberrometry repeatability and agreement-A comparison between Pentacam AXL Wave, iTrace and OPD-Scan III. Ophthalmic Physiol Opt 2022;42:1326–1337.
Koh S, Inoue R, Iwamoto Y, et al. Comparison of ocular wavefront aberration measurements obtained using two Hartmann-shack wavefront aberrometers. Eye Contact Lens 2023;49:98–103.
Saad A, Gatinel D. Evaluation of total and corneal wavefront high order aberrations for the detection of forme fruste keratoconus. Invest Ophthalmol Vis Sci 2012;53:2978–2992.
Naderan M, Jahanrad A, Farjadnia M. Ocular, corneal, and internal aberrations in eyes with keratoconus, forme fruste keratoconus, and healthy eyes. Int Ophthalmol 2018;38:1565–1573.
Ambrósio R Jr, Lopes BT, Faria-Correia F, et al. Integration of Scheimpflug-based corneal tomography and biomechanical assessments for enhancing ectasia detection. J Refract Surg 2017;33:434–443.
Lopes BT, Ramos IC, Salomão MQ, et al. Enhanced tomographic assessment to detect corneal ectasia based on artificial intelligence. Am J Ophthalmol 2018;195:223–232.
Steinberg J, Casagrande MK, Frings A, et al. Screening for subclinical keratoconus using swept-source Fourier domain anterior segment optical coherence tomography. Cornea 2015;34:1413–1419.
Fukuda S, Beheregaray S, Hoshi S, et al. Comparison of three-dimensional optical coherence tomography and combining a rotating Scheimpflug camera with a Placido topography system for forme fruste keratoconus diagnosis. Br J Ophthalmol 2013;97:1554–1559.
Hwang ES, Perez-Straziota CE, Kim SW, et al. Distinguishing highly asymmetric keratoconus eyes using combined Scheimpflug and spectral-domain OCT analysis. Ophthalmology 2018;125:1862–1871.
Zhang H, Tian L, Guo L, et al. Comprehensive evaluation of corneas from normal, forme fruste keratoconus and clinical keratoconus patients using morphological and biomechanical properties. Int Ophthalmol 2021;41:1247–1259.
Kirgiz A, Karaman Erdur S, Atalay K, et al. The role of ocular response analyzer in differentiation of forme fruste keratoconus from corneal astigmatism. Eye Contact Lens 2019;45:83–87.
Li Y, Chamberlain W, Tan O, et al. Subclinical keratoconus detection by pattern analysis of corneal and epithelial thickness maps with optical coherence tomography. J Cataract Refract Surg 2016;42:284–295.
Vinciguerra R, Ambrósio R Jr, Roberts CJ, et al. Biomechanical characterization of subclinical keratoconus without topographic or tomographic abnormalities. J Refract Surg 2017;33:399–407.