Gubernaculum and Epididymo-Testicular Descent: Review of the Literature.
Insl3
cryptorchidism
epididymo-testicular descent
gubernaculum
Journal
Acta medica Lituanica
ISSN: 1392-0138
Titre abrégé: Acta Med Litu
Pays: Lithuania
ID NLM: 9442465
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
04
2022
revised:
21
06
2022
accepted:
21
06
2022
medline:
1
1
2022
pubmed:
1
1
2022
entrez:
21
9
2023
Statut:
ppublish
Résumé
Cryptorchidism is a common disorder in boys that has been widely studied both experimentally and clinically. The role of the gubernaculum, a mesenchymal tissue extending from the fetal testis and epididymis to the developing scrotum, is still unclear. Even the name is debated: 'gubernaculum epididymis' or 'gubernaculum testis'. This review does not aim to provide a global overview of competing theories on testicular descent, but focuses on the role of the gubernaculum in epididymo-testicular descent. We identified four major pitfalls of gubernaculum research: the role of the gubernaculum, of insulin-like peptide 3, anti-Müllerian hormone, and androgens. The major critical issues were that the gubernaculum plays a guiding role for the epididymis, descending prior to the testis and expanding the inguinal canal; insulin-like peptide 3 is not as important for the process of descent in humans as the rate of insulin-like peptide 3 mutations is low; anti-Müllerian hormone plays no significant role in epididymo-testicular descent; androgens and gonadotropins play a crucial role in epididymo-testicular descent. The role of the epididymis in the complex process of gubernaculum, epididymis, and testis migration is underestimated and should be included in future research. Nunusileidusios sėklidės (kriptorchizmas) yra dažna vyriškų lytinių organų patologija. Sėklidės pavadis (lot.
Autres résumés
Type: Publisher
(lit)
Nunusileidusios sėklidės (kriptorchizmas) yra dažna vyriškų lytinių organų patologija. Sėklidės pavadis (lot.
Identifiants
pubmed: 37733393
doi: 10.15388/Amed.2022.29.2.6
pii: Amed.2022.29.2.6
pmc: PMC9799001
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
201-210Informations de copyright
Copyright © 2022 Eleonora Ivanova, Beata Vincel, Gilvydas Verkauskas, Faruk Hadziselimovic. Published by Vilnius University Press.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
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