Botryosphaeria dothidea Mycotic Keratitis: A Novel Phytopathogen Causing Human Infection.
Journal
Cornea
ISSN: 1536-4798
Titre abrégé: Cornea
Pays: United States
ID NLM: 8216186
Informations de publication
Date de publication:
01 Jan 2024
01 Jan 2024
Historique:
received:
29
05
2023
accepted:
14
08
2023
medline:
6
12
2023
pubmed:
21
9
2023
entrez:
21
9
2023
Statut:
ppublish
Résumé
The aim of this study was to report the first case of mycotic keratitis caused by Botryosphaeria dothidea . A 29-year-old man developed a fungal infection after being hit with chestnut thorns in the left eye. In vivo confocal microscopy, microbial culture, and next-generation sequencing (NGS) were used in the diagnosis of mycotic keratitis. The patient was provisionally diagnosed with mycotic keratitis based on IVCM and promptly received local and systemic antifungal treatment with voriconazole and amphotericin B. Although microbial culture failed to identify the pathogen, NGS revealed B. dothidea as the causative agent. Although the infection was quickly contained, corneal perforation still occurred. Owing to the lack of fresh donor corneas, the patient underwent multilayer amniotic membrane and conjunctival pedicle graft surgery. The infection was successfully controlled, and during the 6-month follow-up, the cornea remained clear in the inferotemporal optical zone. We report a novel phytopathogen- B. dothidea -causing mycotic keratitis . Our case indicates that B. dothidea responds well to voriconazole and amphotericin therapy. This case broadens the spectrum of fungal keratitis and highlights the application of NGS in identifying molds.
Identifiants
pubmed: 37733974
doi: 10.1097/ICO.0000000000003393
pii: 00003226-202401000-00021
doi:
Substances chimiques
Voriconazole
JFU09I87TR
Antifungal Agents
0
Amphotericin B
7XU7A7DROE
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
129-132Subventions
Organisme : National Natural Science Foundation of China
ID : 82171025
Organisme : National Natural Science Foundation of China
ID : 82070934
Organisme : Fundamental Research Funds for the Central Universities
ID : HUST: 2019kfyXMBZ065
Organisme : Key Research and Development Program of Hubei Province
ID : 2021BCA146
Organisme : Clinical Research Foundation of Wuhan Union Hospital
ID : 2021xhlcyj03
Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors indicate no potential conflicts of interest.
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