Toxicological profiling of a de novo synthesized benzimidazole derivative with potent and selective proapoptotic potentials against breast cancer.
Antioxidant
Apoptosis
Benzimidazole
Breast cancer
Cytotoxicity
G0/G1 phase arrest
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
26
07
2023
revised:
19
08
2023
accepted:
18
09
2023
medline:
9
10
2023
pubmed:
22
9
2023
entrez:
21
9
2023
Statut:
ppublish
Résumé
This study aimed to investigate the toxicological profile of 1-(6-(1H-benzo[d]imidazole-2-yl)-2-methylpyridin-3-yl) ethanone (BMPE), both in vitro and in vivo. The proapoptotic/necrotic and cell cycle arrest potentials of BMPE were assessed in MCF-7 cell line. The in vivo toxicology was assessed in female Balb/c mice by repeated dosing of 5, 25, and 50 mg/kg for 21 consecutive days, then different biochemical, inflammatory, and oxidative markers were assessed in sera/tissue homogenates of treated animals. The new derivative showed a potent selective cytotoxicity against malignant cell lines with IC
Identifiants
pubmed: 37734466
pii: S0278-6915(23)00451-9
doi: 10.1016/j.fct.2023.114049
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Benzimidazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114049Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.