Evaluation of whole-brain oxygen metabolism in Alzheimer's disease using QSM and quantitative BOLD.

Humans Alzheimer Disease / diagnostic imaging Brain / metabolism Gray Matter / diagnostic imaging Oxygen Respiratory Function Tests Oxygen Consumption / physiology Cerebrovascular Circulation / physiology Magnetic Resonance Imaging
Alzheimer's disease Cerebral blood flow Cerebral metabolic rate of oxygen consumption Oxygen extraction fraction Quantitative susceptibility mapping

Journal

NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515

Informations de publication

Date de publication:
15 11 2023
Historique:
received: 06 02 2023
revised: 14 08 2023
accepted: 18 09 2023
medline: 30 10 2023
pubmed: 22 9 2023
entrez: 21 9 2023
Statut: ppublish

Résumé

The objective of this study was to evaluate the whole-brain pattern of oxygen extraction fraction (OEF), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen consumption (CMRO Twenty-six AD patients and 25 age-matched healthy controls (HC) were prospectively recruited in this study. Mini-Mental State Examination (MMSE) was used to evaluate cognitive status. We applied the QQ-CCTV algorithm which combines quantitative susceptibility mapping and quantitative blood oxygen level-dependent models (QQ) for OEF calculation. CBF map was computed from arterial spin labeling and CMRO Whole brain voxel-wise analysis showed that CBF and CMRO CMRO

Identifiants

DOI: 10.1016/j.neuroimage.2023.120381 PMID: 37734476
pubmed: 37734476
pii: S1053-8119(23)00532-3
doi: 10.1016/j.neuroimage.2023.120381
pii:
doi:

Substances chimiques

Oxygen S88TT14065

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

120381

Informations de copyright

Copyright © 2023. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no conflict of interest.

Auteurs

Aocai Yang (A)

Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, PR China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China.

Hangwei Zhuang (H)

Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA; Department of Radiology, Weill Cornell Medical College, New York, New York 10065, USA.

Lei Du (L)

Department of Radiology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, PR China.

Bing Liu (B)

Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, PR China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China.

Kuan Lv (K)

Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, PR China; Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, PR China.

Jixin Luan (J)

Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, PR China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China.

Pianpian Hu (P)

Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, PR China; Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, PR China.

Feng Chen (F)

Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, Hainan, PR China.

Kai Wu (K)

School of Biomedical Sciences and Engineering, South China University of Technology, Guangdong 510006, Guangzhou, PR China.

Ni Shu (N)

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, PR China.

Amir Shmuel (A)

McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada; Departments of Neurology and Neurosurgery, Physiology, and Biomedical Engineering, McGill University, Montreal, QC, Canada.

Guolin Ma (G)

Department of Radiology, China-Japan Friendship Hospital, Beijing 100029, PR China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, PR China. Electronic address: maguolin1007@qq.com.

Yi Wang (Y)

Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA; Department of Radiology, Weill Cornell Medical College, New York, New York 10065, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Evaluation of whole-brain oxygen metabolism in...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Evaluation of whole-brain oxygen metabolism in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Evaluation of whole-brain oxygen metabolism in...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Substance grise › Evaluation of whole-brain oxygen metabolism in...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Evaluation of whole-brain oxygen metabolism in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic respiratoire › Tests de la fonction respiratoire › Evaluation of whole-brain oxygen metabolism in...
questionsmedicales.fr › Métabolisme › Consommation d'oxygène › Evaluation of whole-brain oxygen metabolism in...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Circulation cérébrovasculaire › Evaluation of whole-brain oxygen metabolism in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Evaluation of whole-brain oxygen metabolism in...