A low dimensional embedding of brain dynamics enhances diagnostic accuracy and behavioral prediction in stroke.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 09 2023
21 09 2023
Historique:
received:
19
05
2023
accepted:
11
09
2023
medline:
25
9
2023
pubmed:
22
9
2023
entrez:
21
9
2023
Statut:
epublish
Résumé
Large-scale brain networks reveal structural connections as well as functional synchronization between distinct regions of the brain. The latter, referred to as functional connectivity (FC), can be derived from neuroimaging techniques such as functional magnetic resonance imaging (fMRI). FC studies have shown that brain networks are severely disrupted by stroke. However, since FC data are usually large and high-dimensional, extracting clinically useful information from this vast amount of data is still a great challenge, and our understanding of the functional consequences of stroke remains limited. Here, we propose a dimensionality reduction approach to simplify the analysis of this complex neural data. By using autoencoders, we find a low-dimensional representation encoding the fMRI data which preserves the typical FC anomalies known to be present in stroke patients. By employing the latent representations emerging from the autoencoders, we enhanced patients' diagnostics and severity classification. Furthermore, we showed how low-dimensional representation increased the accuracy of recovery prediction.
Identifiants
pubmed: 37735201
doi: 10.1038/s41598-023-42533-z
pii: 10.1038/s41598-023-42533-z
pmc: PMC10514061
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15698Informations de copyright
© 2023. Springer Nature Limited.
Références
Sci Rep. 2017 Jun 8;7(1):3095
pubmed: 28596608
Magn Reson Imaging. 2019 Dec;64:101-121
pubmed: 31173849
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Nat Neurosci. 2022 Jun;25(6):783-794
pubmed: 35668174
Neuroimage. 2017 Oct 15;160:84-96
pubmed: 28343985
Sci Rep. 2016 Dec 05;6:38424
pubmed: 27917958
Nat Neurosci. 2014 Nov;17(11):1500-9
pubmed: 25151264
Cereb Cortex Commun. 2022 Nov 02;3(4):tgac045
pubmed: 36479448
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Jul;84(1 Pt 2):016114
pubmed: 21867264
Nat Hum Behav. 2017;1:
pubmed: 28713861
Netw Neurosci. 2023 Oct 01;7(3):1181-1205
pubmed: 37781152
Cell Rep. 2019 Sep 3;28(10):2527-2540.e9
pubmed: 31484066
Proc Natl Acad Sci U S A. 2021 Nov 16;118(46):
pubmed: 34750261
Sci Rep. 2020 Nov 11;10(1):19571
pubmed: 33177575
Neuroscience. 2017 Nov 19;364:212-225
pubmed: 28918259
Nat Rev Neurosci. 2008 Mar;9(3):195-205
pubmed: 18270513
Cell Rep. 2023 May 30;42(5):112491
pubmed: 37171963
Neuroimage Clin. 2022;35:103055
pubmed: 35661469
Front Aging Neurosci. 2017 May 18;9:144
pubmed: 28572765
Front Hum Neurosci. 2012 Dec 28;6:339
pubmed: 23293596
Hum Brain Mapp. 2013 Jun;34(6):1319-29
pubmed: 22331588
Brain Commun. 2021 Oct 23;3(4):fcab233
pubmed: 34729479
Brain. 2017 Apr 1;140(4):1068-1085
pubmed: 28334882
Sci Adv. 2020 Dec 18;6(51):
pubmed: 33355124
Sci Rep. 2018 Feb 19;8(1):3259
pubmed: 29459635
Neuroimage. 2016 Aug 1;136:57-67
pubmed: 27177761
Neuroimage. 2022 May 15;252:118993
pubmed: 35192942
Proc Natl Acad Sci U S A. 1994 May 24;91(11):5033-7
pubmed: 8197179
Neuroimage. 2011 Jan 1;54(1):161-9
pubmed: 20728543
Brain Inform. 2021 Apr 20;8(1):8
pubmed: 33877469
Netw Neurosci. 2020 Dec 01;4(4):1235-1251
pubmed: 33409438
Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Feb;69(2 Pt 2):026113
pubmed: 14995526
PLoS Comput Biol. 2021 Jul 27;17(7):e1009139
pubmed: 34314430
Brain. 2020 Jul 1;143(7):2173-2188
pubmed: 32572442
Neuroimage. 2022 Oct 15;260:119489
pubmed: 35882268
Brain. 2016 Jul;139(Pt 7):2024-38
pubmed: 27225794
Nat Methods. 2013 May;10(5):413-20
pubmed: 23524393
Elife. 2022 Aug 02;11:
pubmed: 35916363
Cereb Cortex. 2018 Sep 1;28(9):3095-3114
pubmed: 28981612
Neuron. 2015 Mar 4;85(5):927-41
pubmed: 25741721
Cortex. 2018 Oct;107:229-237
pubmed: 29357980
Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28393-28401
pubmed: 33093200
Brain Connect. 2012;2(3):125-41
pubmed: 22642651
J Cogn Neurosci. 2012 Jun;24(6):1275-85
pubmed: 22401285
Commun Biol. 2022 Jun 10;5(1):572
pubmed: 35688893
Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4367-76
pubmed: 27402738
Comput Biol Med. 2018 Aug 1;99:38-52
pubmed: 29883752
Cortex. 2018 Apr;101:44-59
pubmed: 29414460
Neuroimage Clin. 2022;36:103233
pubmed: 36272340
Front Hum Neurosci. 2021 Aug 26;15:711279
pubmed: 34512297
Neuroimage. 2018 Sep;178:57-68
pubmed: 29758339
Brain. 2022 May 24;145(4):1338-1353
pubmed: 35025994
Neurology. 2015 Apr 14;84(15):1568-74
pubmed: 25788557
Nat Commun. 2022 May 16;13(1):2693
pubmed: 35577769
JAMA Neurol. 2015 Jun;72(6):713-9
pubmed: 25894231
Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):
pubmed: 34789565
Stroke. 1989 Jul;20(7):864-70
pubmed: 2749846
Trends Neurosci. 2016 Mar;39(3):125-135
pubmed: 26833259
Med Biol Eng Comput. 2018 Jan;56(1):137-157
pubmed: 29119540
Phys Rev E. 2021 Jul;104(1-1):014411
pubmed: 34412335
Curr Biol. 2016 Jul 25;26(14):R656-60
pubmed: 27458907
Nat Neurosci. 2022 Aug;25(8):1093-1103
pubmed: 35902649
Brain. 2014 Sep;137(Pt 9):2408-22
pubmed: 24871646
PeerJ Comput Sci. 2022 Feb 9;8:e782
pubmed: 35494838
Front Neurosci. 2010 Dec 08;4:200
pubmed: 21151783