Strongyloidiasis in humans and dogs in Southern Italy: an observational study.
Dogs
ELISA
Humans
RT-PCR
Strongyloides stercoralis
Journal
Parasitology research
ISSN: 1432-1955
Titre abrégé: Parasitol Res
Pays: Germany
ID NLM: 8703571
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
22
05
2023
accepted:
14
09
2023
medline:
27
11
2023
pubmed:
22
9
2023
entrez:
21
9
2023
Statut:
ppublish
Résumé
Strongyloidiasis is a clinical issue both in humans and in dogs. Moreover, there are concerns about its zoonotic potential. We aimed to explore Strongyloides stercoralis epidemiology in Southern Italy in humans and dogs sharing the same environment in three different settings: (1) kennels (group K); (2) livestock farms (group L) and (3) agricultural farms (group A). For humans, a commercial ELISA test was used for screening. RT-PCR on faecal samples was done for people testing positive or equivocal at serology. On dog's faecal samples, Baermann test and RT-PCR were performed. A total of 145 dogs and 139 persons were tested. Based on faecal tests in dogs and serology in humans, a S. stercoralis positivity of 4.1% and 6.5% was revealed, respectively. The sites where cases were found were different for animals and humans. In dogs the highest positivity was in group K (6.7% against 2% and 0% in L and A). Differently, in humans the proportion of positive results was similar between the groups (p = 0.883). Fifty percent (3/6) of positive dogs were healthy; the other dogs presented weight loss and/or diarrhoea. ELISA-positive persons (n=9) were all in health, but abdominal pain (37.5%), urticaria (22.2%) and asthma (22.2%) were reported, resolving after treatment with oral ivermectin 200 μg/kg. RT-PCR performed on 13 human faecal samples resulted negative. These findings suggest that strongyloidiasis is present in humans and dogs in Southern Italy, and screening in larger cohorts would be needed for more accurate estimates.
Identifiants
pubmed: 37735273
doi: 10.1007/s00436-023-07978-1
pii: 10.1007/s00436-023-07978-1
pmc: PMC10667409
doi:
Substances chimiques
Ivermectin
70288-86-7
Types de publication
Journal Article
Observational Study
Observational Study, Veterinary
Langues
eng
Sous-ensembles de citation
IM
Pagination
2885-2890Informations de copyright
© 2023. The Author(s).
Références
Clin Infect Dis. 2001 Oct 1;33(7):1040-7
pubmed: 11528578
Bull Soc Pathol Exot. 2015 Aug;108(3):171-4
pubmed: 26018388
PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007241
pubmed: 31430282
Acta Vet Scand. 2007 Dec 12;49:37
pubmed: 18076758
Acta Trop. 2019 Feb;190:204-209
pubmed: 30465740
Trends Parasitol. 2023 Apr;39(4):272-284
pubmed: 36804383
Parasit Vectors. 2017 Jul 20;10(1):345
pubmed: 28728589
Parasitology. 2017 Mar;144(3):263-273
pubmed: 27181117
Trans R Soc Trop Med Hyg. 2009 Apr;103(4):342-6
pubmed: 19195671
PLoS Negl Trop Dis. 2018 Feb 9;12(2):e0006229
pubmed: 29425193
Pathogens. 2020 Jun 03;9(6):
pubmed: 32503315
Sci Rep. 2017 Jul 7;7(1):4844
pubmed: 28687738
Front Microbiol. 2016 Nov 08;7:1778
pubmed: 27877170
Parasitology. 2019 Feb;146(2):246-252
pubmed: 30058514
Lancet Infect Dis. 2019 Nov;19(11):1181-1190
pubmed: 31558376
Euro Surveill. 2016 Aug 4;21(31):
pubmed: 27525375
Acta Trop. 2015 Oct;150:210-7
pubmed: 26215130
PLoS Negl Trop Dis. 2017 Aug 9;11(8):e0005752
pubmed: 28793306