Optimal delivery of RNA interference by viral vectors for cancer therapy.
AAV
AV
DNA viruses
HSV
RNA interference
RNA viruses
RNAi therapeutics
VSV
adeno-associated virus
adenovirus
cancer therapeutics
herpes simplex virus
integrating viruses
microRNA
non-replicating viruses
oncolytic viruses
replicating viruses
retroviruses
short hairpin RNA
silencing RNA
vesicular stomatitis virus
viral vectors
Journal
Molecular therapy : the journal of the American Society of Gene Therapy
ISSN: 1525-0024
Titre abrégé: Mol Ther
Pays: United States
ID NLM: 100890581
Informations de publication
Date de publication:
01 11 2023
01 11 2023
Historique:
received:
31
05
2023
revised:
28
08
2023
accepted:
14
09
2023
pmc-release:
01
11
2024
medline:
6
11
2023
pubmed:
22
9
2023
entrez:
22
9
2023
Statut:
ppublish
Résumé
In recent years, there has been a surge in the innovative modification and application of the viral vector-based gene therapy field. Significant and consistent improvements in the engineering, delivery, and safety of viral vectors have set the stage for their application as RNA interference (RNAi) delivery tools. Viral vector-based delivery of RNAi has made remarkable breakthroughs in the treatment of several debilitating diseases and disorders (e.g., neurological diseases); however, their novelty has yet to be fully applied and utilized for the treatment of cancer. This review highlights the most promising and emerging viral vector delivery tools for RNAi therapeutics while discussing the variables limiting their success and suitability for cancer therapy. Specifically, we outline different integrating and non-integrating viral platforms used for gene delivery, currently employed RNAi targets for anti-cancer effect, and various strategies used to optimize the safety and efficacy of these RNAi therapeutics. Most importantly, we provide great insight into what challenges exist in their application as cancer therapeutics and how these challenges can be effectively navigated to advance the field.
Identifiants
pubmed: 37735876
pii: S1525-0016(23)00499-9
doi: 10.1016/j.ymthe.2023.09.012
pmc: PMC10638062
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3127-3145Subventions
Organisme : CIHR
ID : INI-147824
Pays : Canada
Organisme : CIHR
ID : 705952
Pays : Canada
Organisme : CIHR
ID : 377104
Pays : Canada
Organisme : CIHR
ID : 183812
Pays : Canada
Informations de copyright
Copyright © 2023 The American Society of Gene and Cell Therapy. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
J Virol. 1994 Jan;68(1):510-6
pubmed: 8254763
Exp Neurol. 2006 Apr;198(2):382-90
pubmed: 16455076
Annu Rev Biomed Eng. 2008;10:169-94
pubmed: 18647114
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8033-7
pubmed: 8396259
Nat Immunol. 2012 Feb 16;13(3):214-22
pubmed: 22344284
Mol Ther. 2010 Nov;18(11):2028-37
pubmed: 20648001
Nat Med. 2005 Apr;11(4):423-8
pubmed: 15768028
Nat Biotechnol. 2012 Jul 10;30(7):658-70
pubmed: 22781695
Nat Med. 2015 Feb;21(2):178-84
pubmed: 25599133
Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9010-5
pubmed: 19451644
Immunity. 2005 May;22(5):607-19
pubmed: 15894278
Cancer Res. 2006 Oct 1;66(19):9736-43
pubmed: 17018633
J Gen Virol. 2012 Dec;93(Pt 12):2529-2545
pubmed: 23052398
Int J Cancer. 2010 Feb 1;126(3):764-74
pubmed: 19642108
Bioeng Transl Med. 2021 Oct 20;7(1):e10258
pubmed: 35079633
Vaccines (Basel). 2017 Apr 12;5(2):
pubmed: 28417936
Indian J Med Res. 2012 Oct;136(4):571-84
pubmed: 23168697
Sci Rep. 2020 Feb 4;10(1):1779
pubmed: 32019988
Mol Ther. 2003 Jul;8(1):62-71
pubmed: 12842429
PLoS Med. 2006 Apr;3(4):e96
pubmed: 16464133
Int J Pharm. 2008 Apr 16;354(1-2):9-15
pubmed: 17640834
Retrovirology. 2006 Dec 20;3:95
pubmed: 17181864
Cancer Res. 2002 Jul 1;62(13):3743-50
pubmed: 12097284
J Virol. 2002 May;76(9):4580-90
pubmed: 11932423
PLoS One. 2014 Jun 13;9(6):e99341
pubmed: 24926995
Gene Ther. 2003 Apr;10(8):706-11
pubmed: 12692599
Nucleic Acids Res. 2010 Dec;38(22):8328-37
pubmed: 20705652
J Virol. 2006 Jun;80(11):5168-78
pubmed: 16698997
Science. 2013 Oct 11;342(6155):235-8
pubmed: 24115438
J Gen Virol. 1975 Jan;26(1):15-20
pubmed: 1168239
Oncotarget. 2016 Aug 23;7(34):55352-55367
pubmed: 27438146
J Virol. 2010 Oct;84(19):10074-86
pubmed: 20631131
Genomics Proteomics Bioinformatics. 2010 Sep;8(3):170-9
pubmed: 20970745
Nat Rev Cancer. 2018 Nov;18(11):696-705
pubmed: 30293088
Exp Mol Pathol. 2014 Apr;96(2):207-11
pubmed: 24440736
Appl Microbiol Biotechnol. 2021 Jun;105(12):5257
pubmed: 34142208
Cancer Gene Ther. 2011 Aug;18(8):571-8
pubmed: 21660062
Apoptosis. 2016 Mar;21(3):351-64
pubmed: 26677013
BMC Med Genomics. 2012 Sep 06;5:40
pubmed: 22954303
Nat Rev Drug Discov. 2019 May;18(5):358-378
pubmed: 30710128
Nat Neurosci. 2005 Oct;8(10):1343-9
pubmed: 16136043
Nucleic Acids Res. 2012 Mar;40(5):2210-23
pubmed: 22080551
Mol Ther. 2006 Nov;14(5):735-44
pubmed: 16784893
Silence. 2011 Oct 26;2:8
pubmed: 22029761
Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13110-5
pubmed: 17670939
Oncol Lett. 2020 Apr;19(4):3079-3088
pubmed: 32256808
J Transl Med. 2016 Oct 12;14(1):288
pubmed: 27729044
Neuro Oncol. 2018 Jan 22;20(2):215-224
pubmed: 29016934
Gene Ther. 2008 Nov;15(22):1500-10
pubmed: 18509380
Nat Struct Mol Biol. 2005 Nov;12(11):952-7
pubmed: 16228003
Curr Gene Ther. 2005 Aug;5(4):387-98
pubmed: 16101513
Nucleic Acids Res. 2016 May 5;44(8):3865-77
pubmed: 26921406
Brain Res. 2014 Oct 24;1586:46-63
pubmed: 25152470
Mol Ther. 2019 Jan 2;27(1):230-243
pubmed: 30341009
Signal Transduct Target Ther. 2021 Feb 8;6(1):53
pubmed: 33558455
Nat Commun. 2020 Jul 30;11(1):3801
pubmed: 32732879
J Immunol. 2006 Oct 15;177(8):5639-46
pubmed: 17015752
J Gen Virol. 2004 Apr;85(Pt 4):983-991
pubmed: 15039540
Cancer Res. 2004 Apr 15;64(8):2663-7
pubmed: 15087375
Oncogene. 2010 Jul 8;29(27):3990-6
pubmed: 20473328
Front Oncol. 2014 Jul 23;4:191
pubmed: 25101247
RNA. 2005 Feb;11(2):220-6
pubmed: 15613540
Drugs. 2018 Oct;78(15):1625-1631
pubmed: 30251172
Mol Ther. 2010 May;18(5):977-82
pubmed: 20234342
J Gene Med. 2011 Mar;13(3):188-97
pubmed: 21449035
Sci China Life Sci. 2012 Feb;55(2):109-18
pubmed: 22415681
Virol J. 2010 Feb 11;7:35
pubmed: 20149250
Nature. 2001 May 24;411(6836):494-8
pubmed: 11373684
Mol Ther Oncolytics. 2018 Apr 12;9:30-40
pubmed: 29988512
Mol Ther Oncolytics. 2020 Jun 01;18:14-23
pubmed: 32637577
J Virol. 2020 Jan 17;94(3):
pubmed: 31694938
Cancer Res. 2007 Jun 1;67(11):5345-53
pubmed: 17545615
Virology. 1995 Dec 1;214(1):222-8
pubmed: 8525619
Drug Des Devel Ther. 2020 Mar 13;14:1127-1141
pubmed: 32214798
Vaccine. 2010 Jan 22;28(4):950-7
pubmed: 19925902
Gene Ther. 2021 Aug;28(7-8):422-434
pubmed: 32152434
Nucleic Acids Res. 2013 Nov;41(21):e199
pubmed: 24049077
J Gene Med. 2009 Jul;11(7):559-69
pubmed: 19434604
Nat Commun. 2020 Mar 13;11(1):1395
pubmed: 32170083
Hum Gene Ther. 2016 Dec;27(12):947-961
pubmed: 27897038
J Exp Clin Cancer Res. 2009 Jun 15;28:81
pubmed: 19527508
Biophys Rev. 2018 Feb;10(1):69-86
pubmed: 29327101
J Mol Med (Berl). 2013 Jun;91(6):715-25
pubmed: 23292172
Mol Ther. 2007 Feb;15(2):295-302
pubmed: 17235307
Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18206-11
pubmed: 15608064
Proc Natl Acad Sci U S A. 2014 May 13;111(19):7108-13
pubmed: 24778219
Gene Ther. 2007 Mar;14(5):459-64
pubmed: 17051250
Mol Cell. 2015 Jul 2;59(1):117-24
pubmed: 26140367
Mol Ther. 2008 Sep;16(9):1630-6
pubmed: 18665161
Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13421-6
pubmed: 18755897
Hum Gene Ther. 2005 Dec;16(12):1404-12
pubmed: 16390271
Mol Ther. 2005 Nov;12(5):803-12
pubmed: 16112910
Int J Mol Med. 2018 Sep;42(3):1283-1294
pubmed: 29901096
Oncotarget. 2016 Aug 2;7(31):49143-49155
pubmed: 27172795
Methods Enzymol. 2012;507:199-228
pubmed: 22365776
Cell Signal. 2019 Dec;64:109391
pubmed: 31421224
Nat Rev Microbiol. 2013 Mar;11(3):169-80
pubmed: 23411862
Mol Ther Nucleic Acids. 2021 Jan 01;23:1020-1034
pubmed: 33614248
Nat Microbiol. 2016 Dec 05;2:16250
pubmed: 27918527
Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4812-E4821
pubmed: 28559317
Genes Dis. 2017 Jun;4(2):43-63
pubmed: 28944281
Nat Biotechnol. 2016 Feb;34(2):204-9
pubmed: 26829320
Cell Res. 2007 Mar;17(3):187-94
pubmed: 17310219
Int J Oncol. 2019 Feb;54(2):407-419
pubmed: 30570109
Methods Mol Biol. 2010;629:141-58
pubmed: 20387148
J Cancer Res Clin Oncol. 2013 Jun;139(6):933-41
pubmed: 23443256
Nature. 1973 Feb 23;241(5391):545
pubmed: 4632782
Gene Ther. 1999 Dec;6(12):1982-7
pubmed: 10637449
Sci Transl Med. 2010 Jun 16;2(36):36ra43
pubmed: 20555022
J Immunother Cancer. 2018 Jun 19;6(1):62
pubmed: 29921327
Nat Rev Genet. 2016 May;17(5):272-83
pubmed: 27040487
Biochem Pharmacol. 2021 Jul;189:114432
pubmed: 33513339
Cell Host Microbe. 2012 Aug 16;12(2):200-10
pubmed: 22901540
J Clin Invest. 2010 Sep;120(9):3106-19
pubmed: 20697157
Cancer Gene Ther. 2015 Aug;22(8):380-6
pubmed: 26138562
Adv Drug Deliv Rev. 2009 Jul 25;61(9):746-59
pubmed: 19389436
Hum Gene Ther. 2001 May 20;12(8):921-32
pubmed: 11387057
Expert Opin Biol Ther. 2006 Feb;6(2):135-45
pubmed: 16436039
Oncoimmunology. 2015 Dec 8;5(1):e1115641
pubmed: 26942095
Br J Cancer. 2018 Jan;118(1):9-16
pubmed: 29319049
Mol Ther. 2010 May;18(5):888-95
pubmed: 20234341
J Virol. 1998 Dec;72(12):10148-56
pubmed: 9811755
Gene Ther. 2008 May;15(9):635-51
pubmed: 18273054
Nucleic Acids Res. 2013 Apr 1;41(6):3723-33
pubmed: 23376931
Methods Mol Biol. 2005;309:261-72
pubmed: 15990406
Nature. 1998 Feb 19;391(6669):806-11
pubmed: 9486653
Mol Ther. 2002 Mar;5(3):329-35
pubmed: 11863424
Biochemistry. 2009 Mar 24;48(11):2307-9
pubmed: 19249868
Stem Cells. 2015 Mar;33(3):870-9
pubmed: 25524029
Tumour Biol. 2015 Aug;36(8):6037-43
pubmed: 25736927
EMBO J. 1993 May;12(5):2099-108
pubmed: 8491198
J Virol Methods. 2017 Dec;250:47-54
pubmed: 28918073
Hum Gene Ther. 2008 Dec;19(12):1383-400
pubmed: 18771358
Clin Cancer Res. 2004 Oct 15;10(20):7063-70
pubmed: 15501986
J Virol. 2008 Nov;82(22):11009-15
pubmed: 18799589
Curr Gene Ther. 2004 Mar;4(1):41-51
pubmed: 15032613
Antiviral Res. 2013 May;98(2):305-13
pubmed: 23523766
Oncogene. 2003 Aug 28;22(36):5712-5
pubmed: 12944921
Nat Biotechnol. 2005 Jun;23(6):709-17
pubmed: 15908939
Cell. 2004 Jan 23;116(2):205-19
pubmed: 14744432
Mol Ther. 2007 Jun;15(6):1182-8
pubmed: 17406343
Mol Ther Nucleic Acids. 2019 Sep 6;17:452-454
pubmed: 31330496
Hum Gene Ther. 2003 Jan 20;14(2):117-27
pubmed: 12614563
Virus Genes. 2006 Jun;32(3):299-306
pubmed: 16732482
J Virol. 2007 Apr;81(7):3170-80
pubmed: 17229689
Am J Transl Res. 2016 Sep 15;8(9):3822-3830
pubmed: 27725862
Hematol Oncol Clin North Am. 2017 Oct;31(5):753-770
pubmed: 28895845
J Virol. 2002 Aug;76(16):8475-84
pubmed: 12134052
Virol J. 2013 Jun 07;10:185
pubmed: 23759022
Nat Med. 2008 Nov;14(11):1278-83
pubmed: 18953352
Mol Ther. 2008 Aug;16(8):1437-43
pubmed: 18560417
RNA. 2010 Nov;16(11):2068-74
pubmed: 20841420
Cell. 2009 Jun 12;137(6):1005-17
pubmed: 19524505
Cancer Gene Ther. 2006 Nov;13(11):1023-32
pubmed: 16810314
Mol Ther. 2005 Nov;12(5):842-51
pubmed: 16257382
Mol Ther Oncolytics. 2020 Jan 25;16:219-229
pubmed: 32123722
J Pharm Sci. 2007 Nov;96(11):2922-30
pubmed: 17518360
Cancer Rep (Hoboken). 2020 Jun;3(3):e1231
pubmed: 32671980
Cell Rep. 2018 Jan 2;22(1):1-7
pubmed: 29298413
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7306-11
pubmed: 23589850
Nature. 2007 Jul 5;448(7149):39-43
pubmed: 17572664
Mol Ther. 2005 Nov;12(5):900-9
pubmed: 16115802
Mol Cancer Ther. 2022 Mar 1;21(3):460-470
pubmed: 35027480
Mol Ther Methods Clin Dev. 2022 Dec 02;28:28-39
pubmed: 36588821
Gene Ther. 2006 Mar;13(6):553-8
pubmed: 16397511
Sci Rep. 2019 Feb 12;9(1):1839
pubmed: 30755626
Mol Ther. 2002 Sep;6(3):349-58
pubmed: 12231171
Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10238-43
pubmed: 18632556
Mol Ther Methods Clin Dev. 2016 Apr 06;3:16018
pubmed: 27088104
PLoS Pathog. 2007 Jun;3(6):e86
pubmed: 17590081
Cell Cycle. 2006 Sep;5(18):2103-9
pubmed: 16940756
Virus Genes. 2008 Feb;36(1):141-6
pubmed: 18172750
Tumour Biol. 2015 Nov;36(11):9073-81
pubmed: 26084613
Retrovirology. 2005 Aug 18;2:53
pubmed: 16109172
J Virol. 2006 Dec;80(24):12236-47
pubmed: 17020948
J Clin Invest. 2006 Dec;116(12):3204-10
pubmed: 17143329
Mol Cancer Ther. 2016 Jul;15(7):1436-51
pubmed: 27196772
Methods. 2004 Jun;33(2):179-86
pubmed: 15121173
Science. 2002 Apr 19;296(5567):550-3
pubmed: 11910072
J Gene Med. 2006 Apr;8(4):433-41
pubmed: 16389634
Gene Ther. 2013 Sep;20(9):949-57
pubmed: 23615186
J Neurosci. 2010 Oct 20;30(42):13966-76
pubmed: 20962218
Semin Oncol. 2005 Dec;32(6):573-82
pubmed: 16338423
Nat Commun. 2022 Apr 7;13(1):1898
pubmed: 35393414
PLoS Pathog. 2010 Feb 12;6(2):e1000764
pubmed: 20169186
Gene Ther. 2002 Dec;9(24):1730-4
pubmed: 12457288
J Virol. 1998 Dec;72(12):9873-80
pubmed: 9811723
Mol Ther. 2012 Feb;20(2):367-75
pubmed: 22086233
J Control Release. 2015 Apr 10;203:1-15
pubmed: 25660205
Clin Exp Immunol. 2011 Aug;165(2):180-9
pubmed: 21592111
J Immunother Cancer. 2016 Sep 20;4:53
pubmed: 27660707
Dev Cell. 2019 Sep 23;50(6):716-728.e6
pubmed: 31402283
Oncol Rep. 2012 Jul;28(1):21-6
pubmed: 22552490
Nucleic Acids Res. 2003 Sep 1;31(17):e100
pubmed: 12930974
Oncogene. 2005 Nov 21;24(52):7656-72
pubmed: 16299527
Mol Ther Methods Clin Dev. 2018 Mar 16;9:234-246
pubmed: 29766031
Pharmaceutics. 2011 Jul 11;3(3):338-53
pubmed: 24310584
Nature. 2006 May 25;441(7092):537-41
pubmed: 16724069
Sci Transl Med. 2014 Jun 11;6(240):240ps7
pubmed: 24920658
Mol Ther. 2004 Mar;9(3):419-27
pubmed: 15006609
Mol Ther Nucleic Acids. 2015 Sep 15;4:e252
pubmed: 26372022