Promoting metabolic inefficiency for metabolic disease.
Human metabolism
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
20 Oct 2023
20 Oct 2023
Historique:
medline:
22
9
2023
pubmed:
22
9
2023
entrez:
22
9
2023
Statut:
epublish
Résumé
Recent advances in pharmacotherapies that promote appetite suppression have shown remarkable weight loss. Therapies targeting energy expenditure lag behind, and as such none have yet been identified to be safe and efficacious for sustaining negative energy balance toward weight loss. Multiple energy dissipating pathways have been identified in adipose tissue and muscle. The molecular effectors of some of these pathways have been identified, but much is still left to be learned about their regulation. Understanding the molecular underpinnings of metabolic inefficiency in adipose tissue and muscle is required if these pathways are to be therapeutically targeted in the context of obesity and obesity-accelerated diseases.
Identifiants
pubmed: 37736043
doi: 10.1016/j.isci.2023.107843
pii: S2589-0042(23)01920-X
pmc: PMC10510070
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
107843Informations de copyright
© 2023 The Author.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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