Costunolide prevents renal ischemia-reperfusion injury in rats by reducing autophagy, apoptosis, inflammation, and DNA damage.
Apoptosis
Autophagy
Costunolide
Rat
Renal ischemia-reperfusion
Journal
Iranian journal of basic medical sciences
ISSN: 2008-3866
Titre abrégé: Iran J Basic Med Sci
Pays: Iran
ID NLM: 101517966
Informations de publication
Date de publication:
2023
2023
Historique:
received:
14
04
2023
accepted:
30
05
2023
medline:
22
9
2023
pubmed:
22
9
2023
entrez:
22
9
2023
Statut:
ppublish
Résumé
Renal ischemia-reperfusion (I/R) is a vital health condition leading to acute kidney injury. Costunolide (COST) is an actively used molecule clinically for its anti-inflammatory, antioxidant, and immunomodulatory properties. In the present study, we searched for the possible protective effects of COST against renal ischemia/reperfusion (I/R) injury in rats. We established a renal I/R rat model. We divided forty rats into four groups: group I (sham), group II (I/R), group III (I/R+COST 5 mg/kg), and group IV (I/R+COST 10 mg/kg). We collected blood, kidney, and lung samples for analysis. COST administration performed anti-oxidant and anti-inflammatory activity by reducing oxidant parameters and proinflammatory cytokine levels. COST alleviated DNA damage through declining 8-hydroxydeoxyguanosine (8-OHdG) levels. In addition, COST diminished tubular damage and inflammation by reducing kidney injury molecule-1 (KIM-1) production. COST administration also ameliorated apoptosis and autophagy by decreasing caspase-3 and microtubule-associated protein light chain 3B (MAPLC3, LC3B) expression. COST demonstrated protective effects against renal I/R-induced injury.
Identifiants
pubmed: 37736519
doi: 10.22038/IJBMS.2023.71779.15596
pmc: PMC10510491
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1168-1176Déclaration de conflit d'intérêts
The authors reported no potential conflicts of interest.
Références
Br Med Bull. 1993 Jul;49(3):481-93
pubmed: 8221017
J Leukoc Biol. 2005 May;77(5):598-625
pubmed: 15689384
Kidney Int. 2019 Jan;95(1):50-56
pubmed: 30606429
J Ethnopharmacol. 2018 Mar 1;213:256-261
pubmed: 29158156
Rev Inst Med Trop Sao Paulo. 2017 Jun 01;59:e25
pubmed: 28591253
Int J Mol Sci. 2019 Jun 14;20(12):
pubmed: 31208018
Exp Biol Med (Maywood). 2022 Apr;247(8):691-699
pubmed: 35068213
Kidney Int. 2002 Jul;62(1):237-44
pubmed: 12081583
Kidney Blood Press Res. 2012;36(1):220-30
pubmed: 23147260
Cancer Res. 2001 Jul 15;61(14):5378-81
pubmed: 11454679
Eur J Pharmacol. 2014 May 5;730:107-15
pubmed: 24625594
Phytomedicine. 2014 Oct 15;21(12):1638-44
pubmed: 25442271
J Invest Dermatol. 1982 Mar;78(3):206-9
pubmed: 6276474
J Ethnopharmacol. 2021 Jun 28;274:114020
pubmed: 33716080
Anesthesiology. 2020 Mar;132(3):461-475
pubmed: 31794513
Nat Cell Biol. 2018 Dec;20(12):1338-1348
pubmed: 30482941
Biochem Biophys Res Commun. 2004 Jan 2;313(1):171-7
pubmed: 14672714
Cell. 2008 Apr 18;133(2):235-49
pubmed: 18423196
Arch Biochem Biophys. 2020 Sep 30;691:108512
pubmed: 32712291
Exp Mol Pathol. 2020 Feb;112:104329
pubmed: 31697931
J Surg Res. 2017 Dec;220:40-45
pubmed: 29180209
Cell Physiol Biochem. 2018;46(4):1650-1667
pubmed: 29694958
Molecules. 2016 Jul 09;21(7):
pubmed: 27409597
Anesth Analg. 2007 Oct;105(4):1027-33, table of contents
pubmed: 17898383
Nat Rev Nephrol. 2018 Oct;14(10):607-625
pubmed: 30135570
Nature. 2000 Oct 12;407(6805):770-6
pubmed: 11048727
Nat Rev Nephrol. 2015 Feb;11(2):88-101
pubmed: 25331787
Am J Physiol Renal Physiol. 2009 Jul;297(1):F125-37
pubmed: 19403643
Anal Biochem. 1979 Jun;95(2):351-8
pubmed: 36810
Biochem Biophys Res Commun. 2019 Mar 5;510(2):329-333
pubmed: 30709583
Life Sci. 2020 Feb 1;242:117217
pubmed: 31884094
Tumour Biol. 2014 Aug;35(8):7317-26
pubmed: 24838948
J Am Soc Nephrol. 2016 May;27(5):1288-99
pubmed: 26860342
J Clin Med. 2021 Apr 12;10(8):
pubmed: 33921503
Int Immunopharmacol. 2020 Jul;84:106567
pubmed: 32413737
Biomed Pharmacother. 2021 Feb;134:111097
pubmed: 33341051
Transpl Immunol. 2019 Dec;57:101241
pubmed: 31446153
Anal Biochem. 1968 Oct 24;25(1):192-205
pubmed: 4973948
Nat Cell Biol. 2019 Mar;21(3):372-383
pubmed: 30778222
Br J Pharmacol. 2020 Jan;177(2):372-387
pubmed: 31621893
Kidney Int. 2019 Nov;96(5):1083-1099
pubmed: 31443997
J Biol Chem. 1998 Feb 13;273(7):4135-42
pubmed: 9461608
Int Immunopharmacol. 2021 Aug;97:107688
pubmed: 33932695
Am J Transl Res. 2019 Mar 15;11(3):1219-1229
pubmed: 30972157
Am J Physiol Renal Physiol. 2020 Apr 1;318(4):F994-F1005
pubmed: 32068461
Shock. 2012 Aug;38(3):320-7
pubmed: 22777112
Ren Fail. 2019 Nov;41(1):80-87
pubmed: 30909833
Life Sci. 2021 Nov 15;285:120002
pubmed: 34599937
Phytomedicine. 2016 Dec 15;23(14):1843-1852
pubmed: 27912887
Chem Biol Interact. 2010 Dec 5;188(3):467-72
pubmed: 20709041
J Ethnopharmacol. 2016 Nov 4;192:140-147
pubmed: 27396346
Clin J Am Soc Nephrol. 2015 Aug 7;10(8):1324-31
pubmed: 26195505
Life Sci. 2022 Feb 15;291:120271
pubmed: 34974077
Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1098-F1106
pubmed: 29949392
Chem Biol Interact. 2016 Apr 25;250:68-77
pubmed: 26970604
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Oct 1;1064:1-6
pubmed: 28886477
Int Rev Cell Mol Biol. 2012;298:229-317
pubmed: 22878108
Life Sci. 2022 Nov 1;308:120921
pubmed: 36057400