Methiothepin downregulates SNAP-23 and inhibits degranulation of rat basophilic leukemia cells and mouse bone marrow-derived mast cells.
Degranulation
Mast cell
Methiothepin
SNARE
Signal transduction
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
22 Sep 2023
22 Sep 2023
Historique:
revised:
19
08
2023
received:
28
12
2022
accepted:
19
09
2023
pubmed:
22
9
2023
medline:
22
9
2023
entrez:
22
9
2023
Statut:
aheadofprint
Résumé
In the present study, we found that methiothepin (a nonselective 5-hydroxytryptamine [5-HT] receptor antagonist) inhibited antigen-induced degranulation in rat basophilic leukemia cells and mouse bone marrow-derived mast cells. Although antigen stimulation induces release of histamine and serotonin (5-HT) by exocytosis and mast cells express several types of 5-HT receptor, the detailed role of these receptors remains unclear. Here, pretreatment of cells with methiothepin attenuated increased intracellular Ca
Identifiants
pubmed: 37736882
doi: 10.1002/eji.202250360
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2250360Subventions
Organisme : Japan Society for the Promotion of Science, Kakenhi
ID : 18H02564
Informations de copyright
© 2023 Wiley-VCH GmbH.
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