Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness.
Journal
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
ISSN: 1740-634X
Titre abrégé: Neuropsychopharmacology
Pays: England
ID NLM: 8904907
Informations de publication
Date de publication:
22 Sep 2023
22 Sep 2023
Historique:
received:
12
05
2023
accepted:
26
08
2023
revised:
03
08
2023
pubmed:
22
9
2023
medline:
22
9
2023
entrez:
22
9
2023
Statut:
aheadofprint
Résumé
Cognitively impaired and spared patient subgroups were identified in psychosis and depression, and in clinical high-risk for psychosis (CHR). Studies suggest differences in underlying brain structural and functional characteristics. It is unclear whether cognitive subgroups are transdiagnostic phenomena in early stages of psychotic and affective disorder which can be validated on the neural level. Patients with recent-onset psychosis (ROP; N = 140; female = 54), recent-onset depression (ROD; N = 130; female = 73), CHR (N = 128; female = 61) and healthy controls (HC; N = 270; female = 165) were recruited through the multi-site study PRONIA. The transdiagnostic sample and individual study groups were clustered into subgroups based on their performance in eight cognitive domains and characterized by gray matter volume (sMRI) and resting-state functional connectivity (rsFC) using support vector machine (SVM) classification. We identified an impaired subgroup (N
Identifiants
pubmed: 37737273
doi: 10.1038/s41386-023-01729-7
pii: 10.1038/s41386-023-01729-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Brain and Behavior Research Foundation (Brain & Behavior Research Foundation)
ID : 28474
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1105825
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1196508
Organisme : Department of Health | National Health and Medical Research Council (NHMRC)
ID : 1075379
Investigateurs
Mark Sen Dong
(MS)
Anne Erkens
(A)
Eva Gussmann
(E)
Shalaila Haas
(S)
Alkomiet Hasan
(A)
Claudius Hoff
(C)
Ifrah Khanyaree
(I)
Aylin Melo
(A)
Susanna Muckenhuber-Sternbauer
(S)
Janis Kohler
(J)
Omer Faruk Ozturk
(OF)
David Popovic
(D)
Adrian Rangnick
(A)
Sebastian von Saldern
(S)
Rachele Sanfelici
(R)
Moritz Spangemacher
(M)
Ana Tupac
(A)
Maria Fernanda Urquijo
(MF)
Johanna Weiske
(J)
Antonia Wosgien
(A)
Stephan Ruhrmann
(S)
Linda Betz
(L)
Karsten Blume
(K)
Mauro Seves
(M)
Nathalie Kaiser
(N)
Tanja Pilgram
(T)
Thorsten Lichtenstein
(T)
Christiane Woopen
(C)
André Schmidt
(A)
Anita Riecher-Rössler
(A)
Christina Andreou
(C)
Laura Egloff
(L)
Fabienne Harrisberger
(F)
Claudia Lenz
(C)
Letizia Leanza
(L)
Amatya Mackintosh
(A)
Renata Smieskova
(R)
Erich Studerus
(E)
Anna Walter
(A)
Sonja Widmayer
(S)
Katharine Chisholm
(K)
Chris Day
(C)
Sian Lowri Griffiths
(SL)
Mariam Iqbal
(M)
Mirabel Pelton
(M)
Pavan Mallikarjun
(P)
Ashleigh Lin
(A)
Alexander Denissoff
(A)
Anu Ellila
(A)
Tiina From
(T)
Markus Heinimaa
(M)
Tuula Ilonen
(T)
Paivi Jalo
(P)
Heikki Laurikainen
(H)
Maarit Lehtinen
(M)
Antti Luutonen
(A)
Akseli Makela
(A)
Janina Paju
(J)
Henri Pesonen
(H)
Reetta-Liina Armio Säilä
(RL)
Elina Sormunen
(E)
Anna Toivonen
(A)
Otto Turtonen
(O)
Jarmo Hietala
(J)
Mirka Kolkka
(M)
Sinikka Luutonen
(S)
Maija Walta
(M)
Lauri Tuominen
(L)
Ana Beatriz Solana
(AB)
Manuela Abraham
(M)
Nicolas Hehn
(N)
Timo Schirmer
(T)
Carlo Altamura
(C)
Marika Belleri
(M)
Francesca Bottinelli
(F)
Adele Ferro
(A)
Marta Re
(M)
Emiliano Monzani
(E)
Mauro Percudani
(M)
Maurizio Sberna
(M)
Armando D'Agostino
(A)
Lorenzo Del Fabro
(L)
Giampaolo Perna
(G)
Maria Nobile
(M)
Alessandra Alciati
(A)
Matteo Balestrieri
(M)
Giuseppe Cabras
(G)
Franco Fabbro
(F)
Marco Garzitto
(M)
Sara Piccin
(S)
Giuseppe Blasi
(G)
Giulio Pergola
(G)
Grazia Caforio
(G)
Leonardo Facio
(L)
Tiziana Quarto
(T)
Barbara Gelao
(B)
Raffaella Romano
(R)
Ileana Andriola
(I)
Andrea Falsetti
(A)
Marina Barone
(M)
Roberta Passatiore
(R)
Marina Sangiuliano
(M)
Marian Surman
(M)
Olga Bienek
(O)
Frauke Schultze-Lutter
(F)
Christian Schmidt-Kraepelin
(C)
Susanne Neufang
(S)
Alexandra Korda
(A)
Henrik Rohner
(H)
Informations de copyright
© 2023. The Author(s).
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