[Fundamentals in the pathology of testicular germ cell tumours].
Grundlagen der Pathologie von Keimzelltumoren des Hodens.
Choriocarcinoma
Embryonal carcinoma
Seminoma
Teratoma
Yolk sac tumors
Journal
Pathologie (Heidelberg, Germany)
ISSN: 2731-7196
Titre abrégé: Pathologie (Heidelb)
Pays: Germany
ID NLM: 9918384887506676
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
accepted:
26
05
2023
medline:
27
10
2023
pubmed:
22
9
2023
entrez:
22
9
2023
Statut:
ppublish
Résumé
Testicular germ cell tumours (GCT) represent the most common malignant neoplasia in young male adults between the age of 15 and 44. Because of their different biological behaviour it is important to differentiate prepubertal GCTs from postpubertal GCTs. This distinction is made by presence or absence of a germ cell neoplasia in situ. Histopathological diagnostics can be challenging due to different tumour subtypes and their different growth patterns. Therefore, knowledge of morphologic variants and immunohistochemical markers is important. Die Keimzelltumoren des Hodens (engl. „germ cell tumours“, GCT) sind die häufigste maligne Neoplasie bei jungen Männern im Alter von 15–44 Jahren. Aufgrund des biologischen Verhaltens ist eine Unterscheidung zwischen präpubertalen und postpubertalen GCT von großer Bedeutung für den klinischen Verlauf und die Prognose. Diese Unterscheidung erfolgt in Abhängigkeit vom Nachweis einer Keimzellneoplasie in situ und eines Isochromosoms 12p. Die histopathologische Diagnosestellung kann sich aufgrund der verschiedenen Subtypen teilweise schwierig gestalten, weshalb die Kenntnis der unterschiedlichen morphologischen Varianten und verwendbaren immunhistochemischen Marker von großer Bedeutung ist.
Autres résumés
Type: Publisher
(ger)
Die Keimzelltumoren des Hodens (engl. „germ cell tumours“, GCT) sind die häufigste maligne Neoplasie bei jungen Männern im Alter von 15–44 Jahren. Aufgrund des biologischen Verhaltens ist eine Unterscheidung zwischen präpubertalen und postpubertalen GCT von großer Bedeutung für den klinischen Verlauf und die Prognose. Diese Unterscheidung erfolgt in Abhängigkeit vom Nachweis einer Keimzellneoplasie in situ und eines Isochromosoms 12p. Die histopathologische Diagnosestellung kann sich aufgrund der verschiedenen Subtypen teilweise schwierig gestalten, weshalb die Kenntnis der unterschiedlichen morphologischen Varianten und verwendbaren immunhistochemischen Marker von großer Bedeutung ist.
Identifiants
pubmed: 37737316
doi: 10.1007/s00292-023-01223-3
pii: 10.1007/s00292-023-01223-3
doi:
Types de publication
English Abstract
Journal Article
Langues
ger
Sous-ensembles de citation
IM
Pagination
401-413Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
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