Mass Spectrometry-Based Proteogenomics: New Therapeutic Opportunities for Precision Medicine.
drug resistance
oncoproteomics
phosphoproteomics
proteogenomics
single-cell proteomics
Journal
Annual review of pharmacology and toxicology
ISSN: 1545-4304
Titre abrégé: Annu Rev Pharmacol Toxicol
Pays: United States
ID NLM: 7607088
Informations de publication
Date de publication:
23 Jan 2024
23 Jan 2024
Historique:
medline:
24
1
2024
pubmed:
22
9
2023
entrez:
22
9
2023
Statut:
ppublish
Résumé
Proteogenomics refers to the integration of comprehensive genomic, transcriptomic, and proteomic measurements from the same samples with the goal of fully understanding the regulatory processes converting genotypes to phenotypes, often with an emphasis on gaining a deeper understanding of disease processes. Although specific genetic mutations have long been known to drive the development of multiple cancers, gene mutations alone do not always predict prognosis or response to targeted therapy. The benefit of proteogenomics research is that information obtained from proteins and their corresponding pathways provides insight into therapeutic targets that can complement genomic information by providing an additional dimension regarding the underlying mechanisms and pathophysiology of tumors. This review describes the novel insights into tumor biology and drug resistance derived from proteogenomic analysis while highlighting the clinical potential of proteogenomic observations and advances in technique and analysis tools.
Identifiants
pubmed: 37738504
doi: 10.1146/annurev-pharmtox-022723-113921
pmc: PMC10950354
mid: NIHMS1977019
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
455-479Subventions
Organisme : NCI NIH HHS
ID : F30 CA239335
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA271412
Pays : United States
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