The role of interferon in the thymus.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
23
03
2023
revised:
25
08
2023
accepted:
29
08
2023
pmc-release:
01
10
2024
medline:
2
10
2023
pubmed:
23
9
2023
entrez:
22
9
2023
Statut:
ppublish
Résumé
Interferons (IFNs) are a family of proteins that are generated in response to viral infection and induce an antiviral response in many cell types. The COVID-19 pandemic revealed that patients with inborn errors of type-I IFN immunity were more prone to severe infections, but also found that many patients with severe COVID-19 had anti-IFN autoantibodies that led to acquired defects in type-I IFN immunity. These findings revealed the previously unappreciated finding that central immune tolerance to IFN is essential to immune health. Further evidence has also highlighted the importance of IFN within the thymus and its impact on T-cell development. This review will highlight what is known of IFN's role in T-cell development, T-cell central tolerance, and the impact of IFN on the thymus.
Identifiants
pubmed: 37738858
pii: S0952-7915(23)00108-5
doi: 10.1016/j.coi.2023.102389
pmc: PMC10543640
mid: NIHMS1929306
pii:
doi:
Substances chimiques
Interferons
9008-11-1
Interferon Type I
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
102389Subventions
Organisme : NIAID NIH HHS
ID : P01 AI035296
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI039560
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI039560
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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