Signaling protein abundance modulates the strength of the spindle assembly checkpoint.

Humans Cell Cycle Proteins / genetics M Phase Cell Cycle Checkpoints Signal Transduction Kinetochores / metabolism Mitosis Spindle Apparatus / metabolism
cell cycle kinetochore microscopy mitosis signaling spindle assembly checkpoint

Journal

Current biology : CB
ISSN: 1879-0445
Titre abrégé: Curr Biol
Pays: England
ID NLM: 9107782

Informations de publication

Date de publication:
23 10 2023
Historique:
received: 02 01 2023
revised: 19 07 2023
accepted: 24 08 2023
pmc-release: 23 10 2024
medline: 27 10 2023
pubmed: 23 9 2023
entrez: 22 9 2023
Statut: ppublish

Résumé

During mitosis, unattached kinetochores in a dividing cell signal to the spindle assembly checkpoint (SAC) to delay anaphase onset and prevent chromosome missegregation.

Identifiants

DOI: 10.1016/j.cub.2023.08.074 PMID: 37738972 PMC: PMC10615864
pubmed: 37738972
pii: S0960-9822(23)01154-5
doi: 10.1016/j.cub.2023.08.074
pmc: PMC10615864
mid: NIHMS1929422
pii:
doi:

Substances chimiques

Cell Cycle Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

4505-4515.e4

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM126983
Pays : United States

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing financial interests.

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Auteurs

Soubhagyalaxmi Jema (S)

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Chu Chen (C)

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biophysics, University of Michigan, Ann Arbor, MI 48109, USA.

Lauren Humphrey (L)

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Shriya Karmarkar (S)

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Frank Ferrari (F)

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Ajit P Joglekar (AP)

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biophysics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: ajitj@umich.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Signaling protein abundance modulates the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cycle cellulaire › Signaling protein abundance modulates the...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Mitose › Points de contrôle de la phase M du cycle cellulaire › Signaling protein abundance modulates the...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Signaling protein abundance modulates the...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Centromère › Kinétochores › Signaling protein abundance modulates the...
questionsmedicales.fr › Phénomènes génétiques › Division du noyau cellulaire › Mitose › Signaling protein abundance modulates the...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Appareil du fuseau › Signaling protein abundance modulates the...