How it ends: A review of behavioral and psychological phenomena, physiological processes and neural circuits in the termination of aggression in other animals and anger in people.

More is known about aggression initiation and persistence in other animals, and anger in people, than about their cessation. This review summarizes knowledge of relevant factors in aggression, mostly in vertebrates, and anger termination in people. The latency, probability and intensity of offensive aggression in mice is controlled by activity in a neuronal subpopulation in ventromedial hypothalamus [VMH]. This activity instantiates an aggressive state termed angriffsbereitschaft ["attack-readiness"]. Fighting in many species is broken into bouts with interbout breaks due to fatigue and/or signals from dorsal raphe to VMH. Eventually, losers decide durations and outcomes of fighting by transitioning to submission or flight. Factors reducing angriffsbereitschaft and triggering these defeat behaviors could include metabolic costs, e.g., lactate accumulation and glucose depletion detected by the hypothalamus, central fatigue perhaps sensed by the Salience Network [insula and anterior cingulate gyrus] and pain of injuries, the latter insufficiently blunted by opioid and non-opioid stress analgesia and transduced by anterior VMH neurons. Winners' angriffsbereitschaft continue for awhile, as indicated by post-victory attacks and, perhaps, triumph displays of some species, including humans. In longer term situations, sensory and/or response habituation of aggression may explain the "Dear enemy" tolerance of competitive neighbors. Prolonged satiation of predatory behavior could involve habenula-regulated reduction of dopaminergic reward in nucleus accumbens. Termination of human anger involves at least three processes, metaphorically termed decay, quenching and catharsis. Hypothesized neural mechanisms include anger diminution by negative feedback from accumbens to anterior cingulate and/or activity in the Salience Network that controls anger's "accumulation/offset" phase.

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