Pharmacokinetics of remimazolam after intravenous infusion in anaesthetised children.

Adult Child Humans Anesthesia, General Benzodiazepines Infusions, Intravenous Kinetics
CNS7054 benzodiazepine children metabolite paediatric anaesthesia pharmacokinetics remimazolam

Journal

British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541

Informations de publication

Date de publication:
11 2023
Historique:
received: 17 05 2023
revised: 19 07 2023
accepted: 03 08 2023
medline: 27 10 2023
pubmed: 23 9 2023
entrez: 22 9 2023
Statut: ppublish

Résumé

The pharmacokinetic properties of the new benzodiazepine remimazolam have been studied only in adults. We investigated the pharmacokinetics of remimazolam after i.v. infusion in anaesthetised paediatric patients. Twenty-four children (2-6 yr, ASA physical status 1-2, BMI 15-18 kg m Pharmacokinetics were best described by a three-compartment model for remimazolam and a two-compartment model for CNS7054 linked by a transit compartment. Remimazolam showed a high clearance of 15.9 (12.9, 18.2) ml kg Remimazolam in children was characterised by a high clearance and short context-sensitive half-time. When normalised to weight, pharmacokinetic properties were similar to those reported for adults. ChiCTR2200057629.

Sections du résumé

BACKGROUND
The pharmacokinetic properties of the new benzodiazepine remimazolam have been studied only in adults. We investigated the pharmacokinetics of remimazolam after i.v. infusion in anaesthetised paediatric patients.
METHODS
Twenty-four children (2-6 yr, ASA physical status 1-2, BMI 15-18 kg m
RESULTS
Pharmacokinetics were best described by a three-compartment model for remimazolam and a two-compartment model for CNS7054 linked by a transit compartment. Remimazolam showed a high clearance of 15.9 (12.9, 18.2) ml kg
CONCLUSIONS
Remimazolam in children was characterised by a high clearance and short context-sensitive half-time. When normalised to weight, pharmacokinetic properties were similar to those reported for adults.
CLINICAL TRIAL REGISTRATION
ChiCTR2200057629.

Identifiants

DOI: 10.1016/j.bja.2023.08.019 PMID: 37739904
pubmed: 37739904
pii: S0007-0912(23)00472-5
doi: 10.1016/j.bja.2023.08.019
pii:
doi:

Substances chimiques

Benzodiazepines 12794-10-4
remimazolam 7V4A8U16MB

Types de publication

Clinical Trial Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

914-920

Informations de copyright

Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

Auteurs

Yu-Qing Gao (YQ)

Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Harald Ihmsen (H)

Department of Anesthesiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Zhi-Yan Hu (ZY)

Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Wei Sun (W)

Department of Pharmacy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Yu-Bo Fang (YB)

Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Zhen Wang (Z)

Laboratory Medicine Center, Allergy Center, Department of Transfusion Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Jürgen Schüttler (J)

Department of Anesthesiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Christian Jeleazcov (C)

Department of Anesthesiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Hua-Cheng Liu (HC)

Department of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Pediatric Anesthesiology, Ministry of Education, Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Anesthesiology of Zhejiang Province, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: huachengliu@163.com.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Pharmacokinetics of remimazolam after...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Pharmacokinetics of remimazolam after...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Pharmacokinetics of remimazolam after...
questionsmedicales.fr › Anesthésie et analgésie › Anesthésie › Anesthésie générale › Pharmacokinetics of remimazolam after...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Pharmacokinetics of remimazolam after...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Perfusions parentérales › Perfusions veineuses › Pharmacokinetics of remimazolam after...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Pharmacokinetics of remimazolam after...