Changes in salivary microbiota due to gastric cancer resection and its relation to gastric fluid microbiota.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 09 2023
22 09 2023
Historique:
received:
13
04
2023
accepted:
20
09
2023
medline:
25
9
2023
pubmed:
23
9
2023
entrez:
22
9
2023
Statut:
epublish
Résumé
Gastric cancer is one of the leading causes of death worldwide, and resections are performed to cure the disease. We have previously reported the changes in the gastric microbiota after gastric cancer resection, which may be associated with the oral microbiota; however, the changes in the oral microbiota remain uncharacterized. This study aimed to characterize the changes in the salivary microbiota caused by gastric cancer resection and to evaluate their association with the gastric fluid microbiota. Saliva and gastric fluid samples were collected from 63 patients who underwent gastrectomy before and after surgery, and a 16S rRNA metagenomic analysis was performed to compare the microbiota composition. The number of bacterial species in the salivary microbiota decreased, and the bacterial composition changed after the resection of gastric cancer. In addition, we identified several bacterial genera that varied significantly in the salivary microbiota, some of which also showed similar changes in the gastric fluid microbiota. These findings indicate that changes in the gastric environment affect the oral microbiota, emphasizing the close association between the oral and gastric fluid microbiota. Our study signifies the importance of focusing on the oral microbiota in the perioperative period of gastrectomy in patients with gastric cancer.
Identifiants
pubmed: 37740058
doi: 10.1038/s41598-023-43108-8
pii: 10.1038/s41598-023-43108-8
pmc: PMC10516953
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15863Informations de copyright
© 2023. Springer Nature Limited.
Références
Elife. 2019 Mar 19;8:
pubmed: 30885294
Nat Methods. 2018 Dec;15(12):1041-1044
pubmed: 30420687
Gastric Cancer. 2022 Sep;25(5):837-849
pubmed: 35661945
Appl Environ Microbiol. 2010 Aug;76(15):5088-96
pubmed: 20543046
Oral Dis. 2021 Oct;27(7):1847-1853
pubmed: 33191579
Sci Rep. 2022 Jun 22;12(1):10594
pubmed: 35732881
Science. 2015 Sep 4;349(6252):1101-1106
pubmed: 26229116
World J Gastrointest Oncol. 2022 May 15;14(5):959-972
pubmed: 35646287
J Gastroenterol Hepatol. 2022 Feb;37(2):273-279
pubmed: 34837266
Int J Clin Oncol. 2019 Dec;24(12):1558-1564
pubmed: 31332612
Front Cell Infect Microbiol. 2021 Mar 10;11:640309
pubmed: 33777850
BMC Microbiol. 2021 Mar 4;21(1):71
pubmed: 33663382
J Periodontol. 2018 Jun;89 Suppl 1:S159-S172
pubmed: 29926952
Front Cell Infect Microbiol. 2021 Sep 16;11:732613
pubmed: 34604113
Gut. 2022 Jul;71(7):1266-1276
pubmed: 34389621
Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12277-12282
pubmed: 30442671
Gut. 2020 Aug;69(8):1404-1415
pubmed: 31953253
Nat Rev Cancer. 2010 Jun;10(6):403-14
pubmed: 20495574
Cancer Causes Control. 2001 Nov;12(9):847-54
pubmed: 11714113
Protein Cell. 2018 May;9(5):488-500
pubmed: 29736705
Clin Oral Investig. 2022 Jan;26(1):493-504
pubmed: 34143307
PLoS One. 2016 Mar 02;11(3):e0149653
pubmed: 26934048
Gastric Cancer. 2021 Jan;24(1):1-21
pubmed: 32060757
Gut. 2018 Feb;67(2):226-236
pubmed: 29102920
Front Microbiol. 2019 Aug 02;10:1780
pubmed: 31428073
BMC Microbiol. 2022 Feb 12;22(1):53
pubmed: 35151278
Curr Top Microbiol Immunol. 2017;400:253-275
pubmed: 28124157
Sci Rep. 2014 Feb 26;4:4202
pubmed: 24569566
World J Gastroenterol. 2022 Aug 14;28(30):4120-4132
pubmed: 36157109
Front Microbiol. 2021 Mar 15;12:641322
pubmed: 33790881
Elife. 2019 Feb 12;8:
pubmed: 30747106
J Atheroscler Thromb. 2022 Mar 1;29(3):403-421
pubmed: 33612553
Front Cell Infect Microbiol. 2023 Jan 10;12:1105811
pubmed: 36704105
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
J Dent Res. 2020 Aug;99(9):1021-1029
pubmed: 32464078
Front Microbiol. 2020 May 29;11:997
pubmed: 32547510
Clin Sci (Lond). 2022 Sep 30;136(18):1371-1387
pubmed: 36156126
Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):732-7
pubmed: 16407106
Gut. 2018 Jun;67(6):1024-1032
pubmed: 28765474
Clin Oral Investig. 2021 May;25(5):2779-2789
pubmed: 32975702
Lancet Oncol. 2008 Mar;9(3):279-87
pubmed: 18308253
Sci Rep. 2020 Nov 18;10(1):20086
pubmed: 33208788
Int J Oral Sci. 2022 Mar 2;14(1):14
pubmed: 35236828
World J Gastrointest Surg. 2021 Jul 27;13(7):678-688
pubmed: 34354801
ISME J. 2016 Oct;10(10):2435-46
pubmed: 27015003
Microorganisms. 2020 Feb 23;8(2):
pubmed: 32102216
Discov Oncol. 2023 Jan 20;14(1):7
pubmed: 36662326
ISME J. 2013 Jul;7(7):1354-66
pubmed: 23466701
PLoS Biol. 2016 Aug 19;14(8):e1002533
pubmed: 27541692
Semin Cancer Biol. 2022 Nov;86(Pt 3):11-17
pubmed: 35533800
J Dent Res. 2019 Feb;98(2):148-156
pubmed: 30359170
Front Pharmacol. 2020 Jul 07;11:1000
pubmed: 32733243
BMC Microbiol. 2017 Jul 25;17(1):165
pubmed: 28743239