MAIT cells in immune-mediated tissue injury and repair.

Autoimmunity Chronic inflammation MAIT cells Tissue repair

Journal

European journal of immunology

ISSN: 1521-4141

Titre abrégé: Eur J Immunol

Pays: Germany

ID NLM: 1273201

Informations de publication

Date de publication:
23 Sep 2023

Historique:

revised: 20 09 2023

received: 23 06 2023

accepted: 21 09 2023

pubmed: 23 9 2023

medline: 23 9 2023

entrez: 23 9 2023

Statut: aheadofprint

Résumé

Mucosal-associated invariant T (MAIT) cells are T cells that express a semi-invariant αβ T-cell receptor (TCR), recognizing non-peptide antigens, such as microbial-derived vitamin B2 metabolites, presented by the nonpolymorphic MHC class I related-1 molecule. Like NKT cells and γδT cells, MAIT cells belong to the group of innate-like T cells that combine properties of the innate and adaptive immune systems. They account for up to 10% of the blood T-cell population in humans and are particularly abundant at mucosal sites. Beyond the emerging role of MAIT cells in antibacterial and antiviral defenses, increasing evidence suggests additional functions in noninfectious settings, including immune-mediated inflammatory diseases and tissue repair. Here, we discuss recent advances in the understanding of MAIT cell functions in sterile tissue inflammation, with a particular focus on autoimmunity, chronic inflammatory diseases, and tissue repair.

Identifiants

DOI: 10.1002/eji.202350483 PMID: 37740567

pubmed: 37740567

doi: 10.1002/eji.202350483

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Pagination

e2350483

Subventions

Organisme : German Research Foundation - Collaborative Research Centre 1192

ID : 264599542

Organisme : German Research Foundation - Priority Programme 1937

ID : 428069668

Informations de copyright

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