Stem cell antigen-1
Genetic lineage tracing
Myocardial fibrosis
Sca1+ cells
Single-cell RNA sequencing
Transverse aortic constriction
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
23 Sep 2023
23 Sep 2023
Historique:
received:
23
06
2023
accepted:
07
09
2023
revised:
21
08
2023
pubmed:
23
9
2023
medline:
23
9
2023
entrez:
23
9
2023
Statut:
epublish
Résumé
Mesenchymal stem cells (MSCs) present in the heart cannot differentiate into cardiomyocytes, but may play a role in pathological conditions. Therefore, the aim of this study was to scrutinise the role and mechanism of MSC differentiation in vivo during heart failure. We performed single-cell RNA sequencing of total non-cardiomyocytes from murine and adult human hearts. By analysing the transcriptomes of single cells, we illustrated the dynamics of the cell landscape during the progression of heart hypertrophy, including those of stem cell antigen-1 (Sca1) Our study describes the cellular landscape of hypertrophic hearts and reveals that fibroblasts derived from Sca1
Identifiants
pubmed: 37740736
doi: 10.1007/s00018-023-04957-8
pii: 10.1007/s00018-023-04957-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
300Subventions
Organisme : National Natural Science Foundation of China
ID : 82030008
Organisme : National Natural Science Foundation of China
ID : 82270409
Organisme : National Natural Science Foundation of China
ID : 31830039
Organisme : Science and Technology Program of Zhejiang Province
ID : 2023C03087
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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