Hypoxic Microenvironment Reconstruction with Synergistic Biofunctional Ions Promotes Diabetic Wound Healing.
biofunctional ions
diabetic wounds healing
macrophage
oxygen
vascularization
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
23 Sep 2023
23 Sep 2023
Historique:
revised:
14
09
2023
received:
22
06
2023
pubmed:
23
9
2023
medline:
23
9
2023
entrez:
23
9
2023
Statut:
aheadofprint
Résumé
Chronic hypoxia and ischemia make diabetic wounds non-healing. Cellular functions of diabetic chronic wounds are inhibited under a pathological environment. Therefore, this work develops a composite hydrogel system to promote diabetic wound healing. The composite hydrogel system consists of ε-poly-lysine (EPL), calcium peroxide (CP), and borosilicate glass (BG). The hydrogel supplies continuous dissolved oxygen molecules to the wound that can penetrate the skin tissue to restore normal cellular function and promote vascular regeneration. Biofunctional ions released from BGs can recruit more macrophages through neovascularization and modulate macrophage phenotypic transformation. Combining oxygen-mediated vascular regeneration and ion-mediated inflammatory regulation significantly accelerated diabetic wound healing. These findings indicate that this composite hydrogel system holds promise as a novel tissue engineering material.
Identifiants
pubmed: 37740829
doi: 10.1002/adhm.202301984
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2301984Subventions
Organisme : National Key R&D Program of China
ID : 2021YFC2400500
Organisme : National Key R&D Program of China
ID : 2018YFA0703100
Organisme : Marine Six Industry Specialtie of Guangdong
ID : GDNRC[2023]35
Organisme : National Natural Science Foundation of China
ID : 52172286
Organisme : National Natural Science Foundation of China
ID : 51872200
Organisme : National Natural Science Foundation of China
ID : 32000930
Organisme : National Natural Science Foundation of China
ID : U22A20357
Organisme : National Natural Science Foundation of China
ID : 31870956
Organisme : National Natural Science Foundation of China
ID : 52072398
Organisme : National Natural Science Foundation of China
ID : 32161160327
Organisme : National Natural Science Foundation of China
ID : U2001221
Organisme : Shenzhen Science and Technology Program
ID : JSGGKQTD20210831174330015
Organisme : Shenzhen Science and Technology Program
ID : JCYJ20220818101613028
Organisme : Shenzhen Science and Technology Program
ID : ZDSY20130401165820356
Organisme : Shenzhen Science and Technology Program
ID : JCYJ20200109114620793
Informations de copyright
© 2023 Wiley-VCH GmbH.
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