Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
23 09 2023
23 09 2023
Historique:
received:
09
12
2022
accepted:
11
09
2023
medline:
23
10
2023
pubmed:
24
9
2023
entrez:
23
9
2023
Statut:
epublish
Résumé
Microbial infections early in life are challenging for the unexperienced immune system. The SARS-CoV-2 pandemic again has highlighted that neonatal, infant, child, and adult T-helper(Th)-cells respond differently to infections, and requires further understanding. This study investigates anti-bacterial T-cell responses against Staphylococcus aureus aureus, Staphylococcus epidermidis and Bifidobacterium longum infantis in early stages of life and adults and shows age and pathogen-dependent mechanisms. Beside activation-induced clustering, T-cells stimulated with Staphylococci become Th1-type cells; however, this differentiation is mitigated in Bifidobacterium-stimulated T-cells. Strikingly, prestimulation of T-cells with Bifidobacterium suppresses the activation of Staphylococcus-specific T-helper cells in a cell-cell dependent manner by inducing FoxP3
Identifiants
pubmed: 37741816
doi: 10.1038/s41467-023-41630-x
pii: 10.1038/s41467-023-41630-x
pmc: PMC10517955
doi:
Substances chimiques
Anti-Infective Agents
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5943Informations de copyright
© 2023. Springer Nature Limited.
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