An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model.

Humans Animals Retinal Degeneration / therapy Retina Macular Degeneration Models, Animal Electric Stimulation

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
23 09 2023
Historique:
received: 26 04 2023
accepted: 12 08 2023
medline: 25 9 2023
pubmed: 24 9 2023
entrez: 23 9 2023
Statut: epublish

Résumé

Retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) are characterized by unrelenting neuronal death. However, electrical stimulation has been shown to induce neuroprotective changes in the retina capable of slowing down the progression of retinal blindness. In this work, a multi-scale computational model and modeling platform were used to design electrical stimulation strategies to better target the bipolar cells (BCs), that along with photoreceptors are affected at the early stage of retinal degenerative diseases. Our computational findings revealed that biphasic stimulus pulses of long pulse duration could decrease the activation threshold of BCs, and the differential stimulus threshold between ganglion cells (RGCs) and BCs, offering the potential of targeting the BCs during the early phase of degeneration. In vivo experiments were performed to evaluate the electrode placement and parameters found to target bipolar cells and evaluate the safety and efficacy of the treatment. Results indicate that the proposed transcorneal Electrical Stimulation (TES) strategy can attenuate retinal degeneration in a Royal College of Surgeon (RCS) rodent model, offering the potential to translate this work to clinical practice.

Identifiants

DOI: 10.1038/s41598-023-40547-1 PMID: 37741821 PMC: PMC10517961
pubmed: 37741821
doi: 10.1038/s41598-023-40547-1
pii: 10.1038/s41598-023-40547-1
pmc: PMC10517961
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

15924

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Alejandra Gonzalez Calle (A)

Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.

Javad Paknahad (J)

USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
USC Institute for Technology and Medical Systems Innovation, Los Angeles, CA, 90033, USA.

Dimitrios Pollalis (D)

Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.

Pragya Kosta (P)

USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
USC Institute for Technology and Medical Systems Innovation, Los Angeles, CA, 90033, USA.

Biju Thomas (B)

USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.

Ben Yi Tew (BY)

USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
USC Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.

Bodour Salhia (B)

USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
USC Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.

Stan Louie (S)

USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
USC Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, 90089, USA.

Gianluca Lazzi (G)

USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA.
USC Institute for Technology and Medical Systems Innovation, Los Angeles, CA, 90033, USA.

Mark Humayun (M)

Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA. humayun@usc.edu.
USC Ginsburg Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, CA, 90033, USA. humayun@usc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › An extraocular electrical stimulation approach...
questionsmedicales.fr › Eucaryotes › Animaux › An extraocular electrical stimulation approach...
questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Dégénérescence de la rétine › An extraocular electrical stimulation approach...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › An extraocular electrical stimulation approach...
questionsmedicales.fr › Maladies de l'oeil › Rétinopathies › Dégénérescence de la rétine › Dégénérescence maculaire › An extraocular electrical stimulation approach...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › An extraocular electrical stimulation approach...
questionsmedicales.fr › Techniques d'investigation › Stimulation physique › Stimulation électrique › An extraocular electrical stimulation approach...