Alpha synuclein modulates mitochondrial Ca
Journal
NPJ Parkinson's disease
ISSN: 2373-8057
Titre abrégé: NPJ Parkinsons Dis
Pays: United States
ID NLM: 101675390
Informations de publication
Date de publication:
23 Sep 2023
23 Sep 2023
Historique:
received:
18
04
2023
accepted:
08
09
2023
medline:
24
9
2023
pubmed:
24
9
2023
entrez:
23
9
2023
Statut:
epublish
Résumé
Alpha synuclein (a-syn) is an intrinsically disordered protein prevalent in neurons, and aggregated forms are associated with synucleinopathies including Parkinson's disease (PD). Despite the biomedical importance and extensive studies, the physiological role of a-syn and its participation in etiology of PD remain uncertain. We showed previously in model RBL cells that a-syn colocalizes with mitochondrial membranes, depending on formation of N-terminal helices and increasing with mitochondrial stress
Identifiants
pubmed: 37741841
doi: 10.1038/s41531-023-00578-x
pii: 10.1038/s41531-023-00578-x
pmc: PMC10518018
doi:
Types de publication
Journal Article
Langues
eng
Pagination
137Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM136686
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117552
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR025502
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023. Springer Nature Limited.
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