Silc1 long noncoding RNA is an immediate-early gene promoting efficient memory formation.
CP: Molecular biology
CP: Neuroscience
Silc1
Sox11
hippocampus
learning
lncRNAs
long non-coding RNAs
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
31 10 2023
31 10 2023
Historique:
received:
10
01
2023
revised:
30
06
2023
accepted:
08
09
2023
medline:
6
11
2023
pubmed:
24
9
2023
entrez:
24
9
2023
Statut:
ppublish
Résumé
Long noncoding RNAs (lncRNAs) are expressed in many brain circuits and types of neurons; nevertheless, their functional significance for normal brain functions remains elusive. Here, we study the functions in the central nervous system of Silc1, an lncRNA we have shown previously to be important for neuronal regeneration in the peripheral nervous system. We found that Silc1 is rapidly and strongly induced in the hippocampus upon exposure to novelty and is required for efficient spatial learning. Silc1 production is important for induction of Sox11 (its cis-regulated target gene) throughout the CA1-CA3 regions and proper expression of key Sox11 target genes. Consistent with its role in neuronal plasticity, Silc1 levels decline during aging and in models of Alzheimer's disease. Overall, we describe a plasticity pathway in which Silc1 acts as an immediate-early gene to activate Sox11 and induce a neuronal growth-associated transcriptional program important for learning.
Identifiants
pubmed: 37742186
pii: S2211-1247(23)01180-4
doi: 10.1016/j.celrep.2023.113168
pmc: PMC10636608
pii:
doi:
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
113168Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
Références
Nat Commun. 2010 Apr 12;1:9
pubmed: 20596238
Mol Cell. 2020 Mar 5;77(5):1044-1054.e3
pubmed: 31924448
BMC Bioinformatics. 2011 Aug 04;12:323
pubmed: 21816040
Cell Stem Cell. 2015 Apr 2;16(4):439-447
pubmed: 25800779
Sci Adv. 2021 Apr 16;7(16):
pubmed: 33863727
Elife. 2020 Sep 10;9:
pubmed: 32909943
Biochem Biophys Res Commun. 2005 Feb 18;327(3):848-56
pubmed: 15649423
Neuron. 2023 Jul 19;111(14):2140-2154
pubmed: 37230080
Bio Protoc. 2018 Aug 20;8(16):e2475
pubmed: 34395771
J Neurosci. 2012 Feb 29;32(9):3067-80
pubmed: 22378879
Bio Protoc. 2018 Mar 5;8(5):
pubmed: 29651452
Neurosci Res. 2010 Jan;66(1):53-61
pubmed: 19808066
Cell Syst. 2018 Nov 28;7(5):537-547.e3
pubmed: 30447999
Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):716-21
pubmed: 18184812
BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
Neuroscience. 2018 Jul 1;382:93-104
pubmed: 29746989
Nucleic Acids Res. 2021 Jan 8;49(D1):D916-D923
pubmed: 33270111
Dev Dyn. 2013 Jun;242(6):638-53
pubmed: 23483698
Sci Data. 2021 Oct 15;8(1):270
pubmed: 34654824
EMBO J. 2018 Sep 14;37(18):
pubmed: 30177572
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Genome Biol. 2014;15(12):550
pubmed: 25516281
Nat Neurosci. 2017 Mar;20(3):476-483
pubmed: 28166220
Semin Cancer Biol. 2020 Dec;67(Pt 1):3-11
pubmed: 32574812
Nat Rev Genet. 2020 Feb;21(2):102-117
pubmed: 31729473
Front Behav Neurosci. 2018 Apr 25;12:79
pubmed: 29755331
Neuron. 2017 Jun 21;94(6):1112-1120.e4
pubmed: 28641110
Cereb Cortex. 2020 May 18;30(6):3731-3743
pubmed: 32080705
J Biol Chem. 2004 Jul 30;279(31):32603-13
pubmed: 15140899
BMC Genomics. 2018 May 2;19(1):318
pubmed: 29720086
Mol Cell. 2020 Mar 5;77(5):1032-1043.e4
pubmed: 31924447
Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10197-E10205
pubmed: 30297415
eNeuro. 2021 Feb 11;8(1):
pubmed: 33441400
Cell Rep. 2022 Mar 22;38(12):110546
pubmed: 35320727
Elife. 2019 Apr 12;8:
pubmed: 30977723
Eur J Neurosci. 2009 Jun;29(11):2103-14
pubmed: 19490090
Sci Signal. 2019 Jul 02;12(588):
pubmed: 31266852
Brain Res. 2013 Jun 26;1518:9-25
pubmed: 23632380
Dev Dyn. 2011 Jan;240(1):52-64
pubmed: 21117150
Methods. 2016 Apr 1;98:134-142
pubmed: 26611432
Elife. 2016 Apr 26;5:e14997
pubmed: 27113915
Nat Neurosci. 2018 Feb;21(2):290-299
pubmed: 29335606
Cold Spring Harb Symp Quant Biol. 2019;84:165-177
pubmed: 31900326
Oncol Rep. 2021 Sep;46(3):
pubmed: 34318906
Nat Methods. 2013 Dec;10(12):1213-8
pubmed: 24097267
Dev Neurobiol. 2010 Feb;70(2):126-33
pubmed: 19885832
Nucleic Acids Res. 2016 Jul 8;44(W1):W272-6
pubmed: 27185894
Annu Rev Neurosci. 2005;28:223-50
pubmed: 16022595
Biofactors. 2009 May-Jun;35(3):258-65
pubmed: 19422052
Genome Biol. 2008;9(9):R137
pubmed: 18798982
EMBO Rep. 2020 Nov 5;21(11):e51264
pubmed: 32969152
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
PLoS Comput Biol. 2022 Jan 11;18(1):e1009722
pubmed: 35015755
Mol Cell. 2010 May 28;38(4):576-89
pubmed: 20513432
Cell Syst. 2019 Apr 24;8(4):329-337.e4
pubmed: 30954475
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
J Neurosci. 2013 Feb 27;33(9):4066-75
pubmed: 23447615
Cell Rep. 2022 Feb 22;38(8):110398
pubmed: 35196493
Mol Cell. 2018 Nov 1;72(3):553-567.e5
pubmed: 30401432
J Neurosci. 2002 Sep 1;22(17):7548-57
pubmed: 12196578
Nature. 2009 Mar 12;458(7235):223-7
pubmed: 19182780
J Neurochem. 2010 Oct;115(1):131-41
pubmed: 20646169
Cell Mol Life Sci. 2022 Mar 7;79(3):180
pubmed: 35254515
Mol Psychiatry. 2014 Apr;19(4):486-94
pubmed: 23628989
Development. 2010 Mar;137(5):775-84
pubmed: 20147379
Cancer Cell. 2015 Oct 12;28(4):529-540
pubmed: 26461095
Genes Brain Behav. 2008 Oct;7(7):786-95
pubmed: 18616608
Mol Cell Biol. 2004 Aug;24(15):6635-44
pubmed: 15254231
Nat Neurosci. 2019 Oct;22(10):1718-1730
pubmed: 31501571
Cell. 2017 Oct 19;171(3):557-572.e24
pubmed: 29053968
Life Sci Alliance. 2020 Feb 21;3(4):
pubmed: 32086317
Genes Dev. 2011 Dec 1;25(23):2453-64
pubmed: 22085726
Front Mol Neurosci. 2017 Nov 02;10:354
pubmed: 29209164
Nat Commun. 2020 Aug 26;11(1):4267
pubmed: 32848148
Nature. 2011 Aug 28;477(7364):295-300
pubmed: 21874018
Neurobiol Learn Mem. 2021 Sep;183:107486
pubmed: 34214666
J Vis Exp. 2008 Sep 24;(19):
pubmed: 19066539