Effect of ADHD medication on risk of injuries: a preference-based instrumental variable analysis.
ADHD
Injury
Instrumental variable
Pharmacological treatment
Quasi-experiment
Journal
European child & adolescent psychiatry
ISSN: 1435-165X
Titre abrégé: Eur Child Adolesc Psychiatry
Pays: Germany
ID NLM: 9212296
Informations de publication
Date de publication:
24 Sep 2023
24 Sep 2023
Historique:
received:
05
07
2023
accepted:
01
09
2023
medline:
24
9
2023
pubmed:
24
9
2023
entrez:
24
9
2023
Statut:
aheadofprint
Résumé
ADHD is associated with an increased risk of injury. Causal evidence for effects of pharmacological treatment on injuries is scarce. We estimated effects of ADHD medication on injuries using variation in provider preference as an instrumental variable (IV). Using Norwegian registry data, we followed 8051 patients who were diagnosed with ADHD aged 5 to 18 between 2009 and 2011 and recorded their ADHD medication and injuries treated in emergency rooms and emergency wards up to 4 years after diagnosis. Persons with ADHD had an increased risk of injuries compared to the general population (RR 1.35; 95% CI: 1.30-1.39), with higher risk in females (RR 1.47; 95% CI: 1.38-1.56) than males (RR 1.23; 95% CI: 1.18-1.28). The between-clinics variation in provider preference for ADHD medication was large and had a considerable impact on patients' treatment status. There was no causal evidence for protective effects of pharmacological treatment on injuries overall for young individuals with ADHD characterized by milder or atypical symptoms. However, there was an apparent effect of pharmacological treatment over time on the risk of injuries treated at emergency wards in this patient group.
Identifiants
pubmed: 37742289
doi: 10.1007/s00787-023-02294-6
pii: 10.1007/s00787-023-02294-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Helse Vest
ID : 912197
Organisme : Norges Forskningsråd
ID : 288585
Organisme : Norges Forskningsråd
ID : 288585
Organisme : Norges Forskningsråd
ID : 288585
Organisme : Norges Forskningsråd
ID : 288585
Organisme : Norges Forskningsråd
ID : 288585
Organisme : Norges Forskningsråd
ID : 288585
Organisme : Norges Forskningsråd
ID : 288585
Organisme : Norges Forskningsråd
ID : 288585
Organisme : Norges Forskningsråd
ID : 288585
Organisme : Norges Forskningsråd
ID : 288585
Organisme : HORIZON EUROPE European Research Council
ID : 818425
Informations de copyright
© 2023. The Author(s).
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