SIRT1-dependent deacetylation of Txnip H3K9ac is critical for exenatide-improved diabetic kidney disease.

Diabetic kidney disease Exenatide Kidney-specific Sirt1 knockout Txnip

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Nov 2023
Historique:
received: 03 08 2023
revised: 11 09 2023
accepted: 12 09 2023
pubmed: 25 9 2023
medline: 25 9 2023
entrez: 24 9 2023
Statut: ppublish

Résumé

Glucagon-like peptide 1 receptor agonist exenatide (exendin-4) has potential protective capabilities against diabetic kidney disease (DKD). However, the underlying mechanism has not been fully elucidated. The expression of thioredoxin-interacting protein (Txnip) is upregulated during DKD progression by histone acetylation. Sirtuin 1 (SIRT1) is a deacetylase and is decreased in DKD, which indicates that it may regulate Txnip in this disease. Here, we used whole-body heterozygous Sirt1 knockout (Sirt1

Identifiants

DOI: 10.1016/j.biopha.2023.115515 PMID: 37742607
pubmed: 37742607
pii: S0753-3322(23)01313-6
doi: 10.1016/j.biopha.2023.115515
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115515

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflicts of interest, no use of AI nor AI-assisted technologies in the writing process.

Auteurs

Mei-Jun Wang (MJ)

Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, China; Department of Endocrinology and Metabolism, Guangzhou First people's Hospital, Guangzhou, China.

Xiang Cai (X)

Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, China; Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research, The Third Affiliated Hospital of Sun Yat-sen University, China; Medical Center for Comprehensive Weight Control, The Third Affiliated Hospital of Sun Yat-sen University, China.

Ri-Ying Liang (RY)

Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, China; Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

En-Ming Zhang (EM)

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Xiao-Qi Liang (XQ)

Department of Animal Experimental Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Hua Liang (H)

Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, China.

Chang Fu (C)

Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, China.

An-Dong Zhou (AD)

Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, China.

Yi Shi (Y)

Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, China.

Fen Xu (F)

Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, China; Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research, The Third Affiliated Hospital of Sun Yat-sen University, China; Medical Center for Comprehensive Weight Control, The Third Affiliated Hospital of Sun Yat-sen University, China. Electronic address: xufen3@mail.sysu.edu.cn.

Meng-Yin Cai (MY)

Department of Endocrinology & Metabolism, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, China; Guangzhou Municipal Key Laboratory of Mechanistic and Translational Obesity Research, The Third Affiliated Hospital of Sun Yat-sen University, China; Medical Center for Comprehensive Weight Control, The Third Affiliated Hospital of Sun Yat-sen University, China. Electronic address: caimengyin@mail.sysu.edu.cn.

Classifications MeSH