Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension.
Human
Hypertrophy
Hypoxia
Mice
Pulmonary pressure
Remodeling
Journal
Vascular pharmacology
ISSN: 1879-3649
Titre abrégé: Vascul Pharmacol
Pays: United States
ID NLM: 101130615
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
11
10
2022
revised:
04
09
2023
accepted:
21
09
2023
pubmed:
25
9
2023
medline:
25
9
2023
entrez:
24
9
2023
Statut:
ppublish
Résumé
Pulmonary hypertension (PH) is a multifactorial disease with a poor prognosis and inadequate treatment options. We found two-fold higher expression of the orphan G-Protein Coupled Receptor 75 (GPR75) in leukocytes and pulmonary arterial smooth muscle cells from idiopathic PH patients and from lungs of C57BL/6 mice exposed to hypoxia. We therefore postulated that GPR75 signaling is critical to the pathogenesis of PH. To test this hypothesis, we exposed global (Gpr75 Chronic hypoxia increased right ventricular systolic and diastolic pressures in wild-type mice but not Gpr75 These results suggest GPR75 has a significant role in the development of hypoxia-induced PH.
Identifiants
pubmed: 37742819
pii: S1537-1891(23)00095-2
doi: 10.1016/j.vph.2023.107235
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107235Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL132574
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139793
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL166546
Pays : United States
Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.