Decreased Alu methylation in type 2 diabetes mellitus patients increases HbA1c levels.
Alu
DNA methylation
aging
genomic instability
type 2 DM
Journal
Journal of clinical laboratory analysis
ISSN: 1098-2825
Titre abrégé: J Clin Lab Anal
Pays: United States
ID NLM: 8801384
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
revised:
20
08
2023
received:
15
07
2023
accepted:
13
09
2023
medline:
6
11
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
ppublish
Résumé
Alu hypomethylation is a common epigenetic process that promotes genomic instability with aging phenotypes, which leads to type 2 diabetes mellitus (type 2 DM). Previously, our results showed significantly decreased Alu methylation levels in type 2 DM patients. In this study, we aimed to investigate the longitudinal changes in Alu methylation levels in these patients. We observed significantly decreased Alu methylation levels in type 2 DM patients compared with normal (p = 0.0462). Moreover, our findings demonstrated changes in Alu hypomethylation over a follow-up period within the same individuals (p < 0.0001). A reduction in Alu methylation was found in patients with increasing HbA1c levels (p = 0.0013) and directly correlated with increased HbA1c levels in type 2 DM patients (r = -0.2273, p = 0.0387). Alu methylation in type 2 DM patients progressively decreases with increasing HbA1c levels. This observation suggests a potential association between Alu hypomethylation and the underlying molecular mechanisms of elevated blood glucose. Furthermore, monitoring Alu methylation levels may serve as a valuable biomarker for assessing the clinical outcomes of type 2 DM.
Identifiants
pubmed: 37743692
doi: 10.1002/jcla.24966
pmc: PMC10623537
doi:
Substances chimiques
Glycated Hemoglobin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e24966Subventions
Organisme : Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation Grant No. RGNS 63#x2010;213
ID : RGNS 63#x2010;213
Organisme : The National Science and Technology Development Agency, Thailand
ID : P#x2010;19#x2010;50189
Informations de copyright
© 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.
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