Pathway-specific polygenic scores for Alzheimer's disease are associated with changes in brain structure in younger and older adults.
ALSPAC
APOE
Alzheimer’s disease
GWAS
polygenic risk scores
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2023
2023
Historique:
received:
14
11
2022
revised:
17
05
2023
accepted:
23
08
2023
medline:
25
9
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
epublish
Résumé
Genome-wide association studies have identified multiple Alzheimer's disease risk loci with small effect sizes. Polygenic risk scores, which aggregate these variants, are associated with grey matter structural changes. However, genome-wide scores do not allow mechanistic interpretations. The present study explored associations between disease pathway-specific scores and grey matter structure in younger and older adults. Data from two separate population cohorts were used as follows: the Avon Longitudinal Study of Parents and Children, mean age 19.8, and UK Biobank, mean age 64.4 (combined
Identifiants
pubmed: 37744023
doi: 10.1093/braincomms/fcad229
pii: fcad229
pmc: PMC10517196
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcad229Informations de copyright
© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.
Déclaration de conflit d'intérêts
The authors report no competing interests.
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