Survival at older ages: are greater influenza antibody titers protective?
Biomarker
Immunity
Influenza
Sex difference
Survival
Journal
Medical hypotheses
ISSN: 1532-2777
Titre abrégé: Med Hypotheses
Pays: United States
ID NLM: 7505668
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
pmc-release:
01
09
2024
medline:
25
9
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
ppublish
Résumé
Antibodies are a core element of the immune system's defense against infectious diseases. We hypothesize that antibody titres might therefore be an important predictor of survival in older individuals. This is important because biomarkers that robustly measure survival have proved elusive, despite their potential utility in health care settings. We present evidence supporting the hypothesis that influenza antibody titres are associated with overall survival of older individuals, and indicate a role for biological sex in modulating this association. Since antibody titres can be modulated by vaccination, these results have important implications for public health policy on influenza control in aging populations.
Identifiants
pubmed: 37744025
doi: 10.1016/j.mehy.2023.111135
pmc: PMC10512879
mid: NIHMS1928390
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : FIC NIH HHS
ID : R01 TW008246
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG048075
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest: none
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