Preparation, Characterization, and Evaluation of Physcion Nanoparticles for Enhanced Oral Bioavailability: An Attempt to Improve Its Antioxidant and Anticancer Potential.


Journal

ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658

Informations de publication

Date de publication:
19 Sep 2023
Historique:
received: 05 07 2023
accepted: 29 08 2023
medline: 25 9 2023
pubmed: 25 9 2023
entrez: 25 9 2023
Statut: epublish

Résumé

This study aims to enhance the dissolution rate of a poorly water-soluble drug physcion by producing its nanoparticles (NPs) using an antisolvent precipitation with a syringe pump (APSP) method and to assess its antioxidant and cytotoxic potential. The NPs were prepared using a simple and cost-effective APSP method and subsequently characterized by different analytical techniques including dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray powder diffractometry (XRD). They were also subjected to solubility and dissolution studies, and different parameters such as dissolution efficiency (DE), mean dissolution time (MDT), and difference (

Identifiants

pubmed: 37744808
doi: 10.1021/acsomega.3c04821
pmc: PMC10515591
doi:

Types de publication

Journal Article

Langues

eng

Pagination

33955-33965

Informations de copyright

© 2023 The Authors. Published by American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare no competing financial interest.

Références

Biomedicines. 2022 Aug 23;10(9):
pubmed: 36140156
Chem Soc Rev. 2016 Nov 21;45(23):6488-6519
pubmed: 27722560
Am J Cancer Res. 2016 Dec 01;6(12):2919-2931
pubmed: 28042511
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Theranostics. 2016 Mar 21;6(6):762-72
pubmed: 27162548
BMC Res Notes. 2015 Oct 30;8:621
pubmed: 26518275
J Ethnopharmacol. 2015 Jul 1;169:305-13
pubmed: 25907980
Biomed Pharmacother. 2022 Sep;153:113384
pubmed: 35820317
Colloid Polym Sci. 2014;292(10):2453-2464
pubmed: 25242857
Cells. 2021 Aug 08;10(8):
pubmed: 34440797
Malar Res Treat. 2013;2013:769234
pubmed: 23766925
ADMET DMPK. 2020 Jun 29;8(4):411-423
pubmed: 35300193
Drug Des Devel Ther. 2017 May 15;11:1453-1464
pubmed: 28553075
Int J Pharm. 2015 Nov 30;495(2):738-49
pubmed: 26383838
Eur J Pharm Sci. 2003 Feb;18(2):113-20
pubmed: 12594003
Eur J Immunol. 2019 May;49(5):709-723
pubmed: 30802940
Polymers (Basel). 2022 Jan 31;14(3):
pubmed: 35160569
Nanoscale Res Lett. 2021 Dec 5;16(1):173
pubmed: 34866166
Carcinogenesis. 1989 Jun;10(6):1003-8
pubmed: 2470525
ACS Nano. 2018 Jan 23;12(1):24-43
pubmed: 29257865
Oxid Med Cell Longev. 2018 Jul 3;2018:2390234
pubmed: 30057674
Chem Soc Rev. 2014 Mar 7;43(5):1601-11
pubmed: 24342982
Acta Pharmacol Sin. 2016 Feb;37(2):264-75
pubmed: 26707141
Eur Urol. 2016 Nov;70(5):862-874
pubmed: 27289567
Pharm Nanotechnol. 2019;7(4):259-278
pubmed: 30961518
Int J Biomed Sci. 2008 Jun;4(2):89-96
pubmed: 23675073
Biochim Biophys Acta Rev Cancer. 2020 Jan;1873(1):188319
pubmed: 31678141
Antioxidants (Basel). 2023 Feb 04;12(2):
pubmed: 36829937
Anal Chem. 2019 Jun 4;91(11):7411-7417
pubmed: 31050887
Int J Pharm Sci Res. 2015 Oct 1;6(10):4103-4112
pubmed: 26594645
Int J Nanomedicine. 2017 Mar 27;12:2373-2384
pubmed: 28392694
Eur J Pharm Sci. 2021 Jul 1;162:105812
pubmed: 33753215
Molecules. 2018 Apr 04;23(4):
pubmed: 29617302
AAPS J. 2008 Jun;10(2):289-99
pubmed: 18500564
Drug Des Devel Ther. 2018 Feb 14;12:303-312
pubmed: 29491706
Nat Prod Res. 2019 Jan;33(2):280-286
pubmed: 29533086
J Agric Food Chem. 2023 May 17;71(19):7299-7311
pubmed: 37132503
Int J Mol Sci. 2018 Nov 09;19(11):
pubmed: 30423952
J Nutr. 2002 Mar;132(3):461-71
pubmed: 11880572
Saudi Pharm J. 2018 Feb;26(2):177-190
pubmed: 30166914
Molecules. 2020 Aug 15;25(16):
pubmed: 32824172
Science. 2018 Mar 23;359(6382):1350-1355
pubmed: 29567705
J Asian Nat Prod Res. 2010 Dec;12(12):1026-32
pubmed: 21128142
Pharmacogn Rev. 2010 Jul;4(8):118-26
pubmed: 22228951

Auteurs

Fazli Khuda (F)

Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.

Irum Zahir (I)

Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.

Atif Ali Khan Khalil (AAK)

Department of Pharmacognosy, Institute of Pharmacy, Lahore College for Women University, Lahore 54000, Pakistan.

Sajid Ali (S)

Department of Biotechnology, Abdul Wali Khan University, Mardan 23200, Pakistan.

Naveed Ullah (N)

Department of Pharmacy, University of Swabi, Swabi 23430, Pakistan.

Ahmed H Albariqi (AH)

Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.

Mi-Jeong Ahn (MJ)

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.

Muhammad Shafique (M)

Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia.

Sultan Mehtap Büyüker (S)

Department of Pharmacy Services, Üsküdar University, İstanbul 34662, Turkey.

Saud Almawash (S)

Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, Shaqra 11961, Saudi Arabia.

Classifications MeSH