Alcohol and caffeine synergistically induce spontaneous ventricular tachyarrhythmias: ameliorated with dantrolene treatment.
Alcohol
Arrhythmogenesis
Bidirectional ventricular tachycardia
Caffeine
Dantrolene
Ventricular tachyarrhythmia
Journal
Heart rhythm O2
ISSN: 2666-5018
Titre abrégé: Heart Rhythm O2
Pays: United States
ID NLM: 101768511
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
medline:
25
9
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
epublish
Résumé
Alcohol and caffeine are the 2 frequently consumed substances in the general population, and the 2 substances are frequently co-consumed. Both substances may increase cardiac arrhythmia risk. However, it is unknown whether alcohol and caffeine co-consumption can synergistically enhance cardiac arrhythmogenesis. The study sought to investigate whether caffeine and binge drinking synergistically affect cardiac arrhythmogenesis. A binge drinking rat model (alcohol 2 g/kg, intraperitoneal, every other day for 3 times) was used. Rats (4 months old, both sexes) were randomized into the following 4 groups: binge alcohol-only group (A) (n = 8), nonalcohol, caffeine-only (60 mg/kg, intraperitoneal) group (C) (n = 8), binge alcohol plus caffeine group (A+C) (n = 8), and binge alcohol + caffeine + dantrolene group (A+D) (n = 7, treated with dantrolene 10 mg/kg before each alcohol injection). We also investigated whether alcohol induces Ca No arrhythmia was induced with caffeine alone (group C, n = 0 of 8) or alcohol alone (group A, n = 0 of 8). However, alcohol + caffeine induced spontaneous ventricular tachyarrhythmias in all rats (group A+C, n = 8 of 8; Co-consumption of caffeine and binge drinking synergistically promote spontaneous ventricular tachyarrhythmias in rats. Dantrolene treatment can decrease alcohol-enhanced Ca
Sections du résumé
Background
UNASSIGNED
Alcohol and caffeine are the 2 frequently consumed substances in the general population, and the 2 substances are frequently co-consumed. Both substances may increase cardiac arrhythmia risk. However, it is unknown whether alcohol and caffeine co-consumption can synergistically enhance cardiac arrhythmogenesis.
Objective
UNASSIGNED
The study sought to investigate whether caffeine and binge drinking synergistically affect cardiac arrhythmogenesis.
Methods
UNASSIGNED
A binge drinking rat model (alcohol 2 g/kg, intraperitoneal, every other day for 3 times) was used. Rats (4 months old, both sexes) were randomized into the following 4 groups: binge alcohol-only group (A) (n = 8), nonalcohol, caffeine-only (60 mg/kg, intraperitoneal) group (C) (n = 8), binge alcohol plus caffeine group (A+C) (n = 8), and binge alcohol + caffeine + dantrolene group (A+D) (n = 7, treated with dantrolene 10 mg/kg before each alcohol injection). We also investigated whether alcohol induces Ca
Results
UNASSIGNED
No arrhythmia was induced with caffeine alone (group C, n = 0 of 8) or alcohol alone (group A, n = 0 of 8). However, alcohol + caffeine induced spontaneous ventricular tachyarrhythmias in all rats (group A+C, n = 8 of 8;
Conclusion
UNASSIGNED
Co-consumption of caffeine and binge drinking synergistically promote spontaneous ventricular tachyarrhythmias in rats. Dantrolene treatment can decrease alcohol-enhanced Ca
Identifiants
pubmed: 37744935
doi: 10.1016/j.hroo.2023.07.005
pii: S2666-5018(23)00164-2
pmc: PMC10513921
doi:
Types de publication
Journal Article
Langues
eng
Pagination
549-555Informations de copyright
© 2023 Heart Rhythm Society. Published by Elsevier Inc.
Références
Nutrients. 2018 May 14;10(5):
pubmed: 29757951
Am Heart J. 1976 Jan;91(1):66-78
pubmed: 942675
Int J Cardiol. 2021 May 15;331:100-105
pubmed: 33548379
Biochem J. 2008 Sep 15;414(3):441-52
pubmed: 18518861
Am J Physiol. 1962 Jul;203:194-6
pubmed: 13898722
J Mol Cell Cardiol. 2020 Sep;146:69-83
pubmed: 32710981
J Toxicol Clin Toxicol. 1999;37(1):29-33
pubmed: 10078157
Circ Res. 2022 Jun 10;130(12):1926-1964
pubmed: 35679367
J Basic Clin Pharm. 2016 Mar;7(2):27-31
pubmed: 27057123
N Engl J Med. 2020 Jan 2;382(1):20-28
pubmed: 31893513
JACC Clin Electrophysiol. 2023 Feb;9(2):266-279
pubmed: 36858701
Herz. 1996 Aug;21(4):227-31
pubmed: 8805002
Br Heart J. 1992 Nov;68(5):443-8
pubmed: 1467026
J Am Coll Cardiol. 2018 Apr 3;71(13):1459-1470
pubmed: 29598867
J Am Coll Cardiol. 2016 Dec 13;68(23):2567-2576
pubmed: 27931615
Europace. 2016 Feb;18(2):257-66
pubmed: 26443445
Heart Rhythm. 2019 Jul;16(7):996-1002
pubmed: 30772533
Circ Res. 2010 Aug 20;107(4):512-9
pubmed: 20595652
Acta Med Scand. 1987;221(4):335-41
pubmed: 3604749
JAMA Intern Med. 2021 Sep 1;181(9):1185-1193
pubmed: 34279564
Nutr Rev. 2014 Aug;72(8):507-22
pubmed: 24946991
J Mol Cell Cardiol. 2021 Nov;160:1-14
pubmed: 34175303
JACC Clin Electrophysiol. 2018 Apr;4(4):425-432
pubmed: 30067480
Trends Cardiovasc Med. 2019 Aug;29(6):345-350
pubmed: 30301595
Heart Rhythm O2. 2020 Sep 08;1(5):359-367
pubmed: 34113894
Eur J Prev Cardiol. 2022 Dec 7;29(17):2240-2249
pubmed: 36162818
J Am Heart Assoc. 2016 Jan 26;5(1):
pubmed: 26813889
J Addict Res Ther. 2013 Aug 20;Suppl 4:
pubmed: 25419478
J Cardiovasc Pharmacol. 2022 Nov 01;80(5):739-745
pubmed: 35947104
N Engl J Med. 2023 Mar 23;388(12):1092-1100
pubmed: 36947466
JAMA. 1980 May 2;243(17):1723-5
pubmed: 7365935