Biomarkers in sepsis-looking for the Holy Grail or chasing a mirage!
Omics
Presepsin
Procalcitonin
Sepsis
Sepsis biomarkers
Journal
World journal of critical care medicine
ISSN: 2220-3141
Titre abrégé: World J Crit Care Med
Pays: United States
ID NLM: 101622182
Informations de publication
Date de publication:
09 Sep 2023
09 Sep 2023
Historique:
received:
13
03
2023
revised:
12
05
2023
accepted:
12
06
2023
medline:
25
9
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
epublish
Résumé
Sepsis is defined as a life-threatening organ dysfunction caused by the dysregulated host response to infection. It is a complex syndrome and is characterized by physiologic, pathologic and biochemical abnormalities in response to an infection. Diagnosis of sepsis is based on history, physical examination and other investigations (including biomarkers) which may help to increase the certainty of diagnosis. Biomarkers have been evaluated in the past for many diseases and have been evaluated for sepsis as well. Biomarkers may find a possible role in diagnosis, prognostication, therapeutic monitoring and anti-microbial stewardship in sepsis. Since the pathophysiology of sepsis is quite complex and is incompletely understood, a single biomarker that may be robust enough to provide all information has not been found as of yet. However, many biomarkers have been studied and some of them have applications at the bedside and guide clinical decision-making. We evaluated the PubMed database to search for sepsis biomarkers for diagnosis, prognosis and possible role in antibiotic escalation and de-escalation. Clinical trials, meta-analyses, systematic reviews and randomized controlled trials were included. Commonly studied biomarkers such as procalcitonin, Soluble urokinase-type plasminogen activator (Supar), presepsin, soluble triggering receptor expressed on myeloid cells 1, interleukin 6, C-reactive protein,
Identifiants
pubmed: 37745257
doi: 10.5492/wjccm.v12.i4.188
pmc: PMC10515097
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
188-203Informations de copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
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