A latent cardiomyocyte regeneration potential in human heart disease.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
17 Sep 2023
Historique:
pubmed: 25 9 2023
medline: 25 9 2023
entrez: 25 9 2023
Statut: epublish

Résumé

Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospective

Identifiants

DOI: 10.1101/2023.09.14.557681 PMID: 37745322 PMC: PMC10515906
pubmed: 37745322
doi: 10.1101/2023.09.14.557681
pmc: PMC10515906
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : CSRD VA
ID : I01 CX002291
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135121
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL156667
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Auteurs

Wouter Derks (W)

Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.

Julian Rode (J)

Center of Information Services and High-Performance Computing, TU Dresden, Dresden, Germany.

Sofia Collin (S)

Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.

Fabian Rost (F)

Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Center of Information Services and High-Performance Computing, TU Dresden, Dresden, Germany.
DRESDEN-concept Genome Center, Technology Platform at the Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.

Paula Heinke (P)

Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.

Anjana Hariharan (A)

Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.

Lauren Pickel (L)

Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.

Irina Simonova (I)

Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.

Enikő Lázár (E)

Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.

Evan Graham (E)

Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.

Ramadan Jashari (R)

European Homograft Bank, B-1120 Brussels, Belgium.

Michaela Andrä (M)

Department of Cardiothoracic and Vascular Surgery, Klinikum Klagenfurt and Section for Surgical Research Medical University Graz, 9020 Graz, Austria.

Anders Jeppsson (A)

Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Mehran Salehpour (M)

Department of Physics and Astronomy, Applied Nuclear Physics, Uppsala University, SE-751 20 Uppsala, Sweden.

Kanar Alkass (K)

Department of Oncology-Pathology, Karolinska Institute, SE-171 77 Stockholm and National Board of Forensic Medicine, SE-171 65 Stockholm, Sweden.

Henrik Druid (H)

Department of Oncology-Pathology, Karolinska Institute, SE-171 77 Stockholm and National Board of Forensic Medicine, SE-171 65 Stockholm, Sweden.

Christos P Kyriakopoulos (CP)

Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States.

Iosif Taleb (I)

Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States.

Thirupura S Shankar (TS)

Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States.

Craig H Selzman (CH)

Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States.

Hesham Sadek (H)

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Stefan Jovinge (S)

Spectrum Health Frederik Meijer Heart & Vascular Institute and Van Andel Institute, Grand Rapids, MI 49503, USA.

Lutz Brusch (L)

Center of Information Services and High-Performance Computing, TU Dresden, Dresden, Germany.

Jonas Frisén (J)

Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.

Stavros Drakos (S)

Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States.

Olaf Bergmann (O)

Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
Pharmacology and Toxicology, Department of Pharmacology and Toxicology University Medical Center Goettingen, Goettingen, Germany.

Classifications MeSH