Epidermal growth factor receptors in vascular endothelial cells contribute to functional hyperemia in the brain.
Functional hyperemia
cerebral small vessel diseases (cSVD)
epidermal growth factor receptor (EGFR)
phosphatidylinositol 4,5-bisphosphate (PIP2)
vascular endothelial cells
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
17 Sep 2023
17 Sep 2023
Historique:
pubmed:
25
9
2023
medline:
25
9
2023
entrez:
25
9
2023
Statut:
epublish
Résumé
Functional hyperemia - activity-dependent increases in local blood perfusion - underlies the on-demand delivery of blood to regions of enhanced neuronal activity, a process that is crucial for brain health. Importantly, functional hyperemia deficits have been linked to multiple dementia risk factors, including aging, chronic hypertension, and cerebral small vessel disease (cSVD). We previously reported crippled functional hyperemia in a mouse model of genetic cSVD that was likely caused by depletion of phosphatidylinositol 4,5-bisphosphate (PIP
Identifiants
pubmed: 37745396
doi: 10.1101/2023.09.15.557981
pmc: PMC10516026
pii:
doi:
Types de publication
Preprint
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL142888
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM135007
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL140027
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS128963
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110656
Pays : United States
Commentaires et corrections
Type : UpdateIn
Déclaration de conflit d'intérêts
Conflict of Interest: All authors have no conflict to declare.