Interferon-α promotes neo-antigen formation and preferential HLA-B-restricted antigen presentation in pancreatic β-cells.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
17 Sep 2023
Historique:
pubmed: 25 9 2023
medline: 25 9 2023
entrez: 25 9 2023
Statut: epublish

Résumé

Interferon (IFN)-α is the earliest cytokine signature observed in individuals at risk for type 1 diabetes (T1D), but its effect on the repertoire of HLA Class I (HLA-I)-bound peptides presented by pancreatic β-cells is unknown. Using immunopeptidomics, we characterized the peptide/HLA-I presentation in

Identifiants

DOI: 10.1101/2023.09.15.557918 PMID: 37745505 PMC: PMC10516036
pubmed: 37745505
doi: 10.1101/2023.09.15.557918
pmc: PMC10516036
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK133881
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK127786
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK099317
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK116284
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK116073
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK126444
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK104218
Pays : United States

Déclaration de conflit d'intérêts

Competing interests. No potential conflicts of interest relevant to this article were reported.

Auteurs

Alexia Carré (A)

Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.

Zhicheng Zhou (Z)

Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.

Javier Perez-Hernandez (J)

Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Department of Nutrition and Health, Valencian International University (VIU), Valencia, Spain.

Fatoumata Samassa (F)

Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.

Christiana Lekka (C)

Islet Biology Group, Exeter Centre of Excellence in Diabetes Research, University of Exeter Medical School, Exeter, UK.

Anthony Manganaro (A)

Diabetes Center of Excellence, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Masaya Oshima (M)

Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.

Hanqing Liao (H)

Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, UK.

Robert Parker (R)

Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, UK.

Annalisa Nicastri (A)

Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, UK.

Barbara Brandao (B)

Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.

Maikel L Colli (ML)

ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.

Decio L Eizirik (DL)

ULB Center for Diabetes Research, Université Libre de Bruxelles, Brussels, Belgium.

Marcus Göransson (M)

Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark.

Orlando Burgos Morales (OB)

Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.

Amanda Anderson (A)

Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.

Laurie Landry (L)

Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.

Farah Kobaisi (F)

Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.

Raphael Scharfmann (R)

Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.

Lorella Marselli (L)

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Piero Marchetti (P)

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Sylvaine You (S)

Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Indiana Biosciences Research Institute, Indianapolis, IN, USA.

Maki Nakayama (M)

Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, USA.

Sine R Hadrup (SR)

Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark.

Sally C Kent (SC)

Diabetes Center of Excellence, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Sarah J Richardson (SJ)

Islet Biology Group, Exeter Centre of Excellence in Diabetes Research, University of Exeter Medical School, Exeter, UK.

Nicola Ternette (N)

Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, UK.

Roberto Mallone (R)

Université Paris Cité, Institut Cochin, CNRS, INSERM, Paris, France.
Indiana Biosciences Research Institute, Indianapolis, IN, USA.
Assistance Publique Hôpitaux de Paris, Service de Diabétologie et Immunologie Clinique, Cochin Hospital, Paris, France.

Classifications MeSH