Association of serum 25-hydroxyvitamin D with urinary incontinence in elderly men: evidence based on NHANES 2007-2014.
25-hydroxyvitamin D
NHANES
elderly men
urinary incontinence
vitamin D deficiency
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
02
05
2023
accepted:
24
08
2023
medline:
26
9
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
epublish
Résumé
The correlation between serum 25-hydroxyvitamin D (25(OH)D) and different sub-types of urinary incontinence in elderly men continues to be uncertain. Hence, we performed this research to evaluate whether serum 25(OH)D levels are correlated with urinary incontinence among elderly men. The present study incorporated the male population aged 50 years and above from four cycles of the NHANES database spanning from 2007 to 2014, for the purpose of analysis. The assessment of urinary incontinence was carried out through a correlation questionnaire, while standardized liquid chromatography-tandem mass spectrometry (LC-MS/MS) was adopted to quantify serum 25(OH)D. A weighted multi-factorial logistic regression analysis was carried out to ascertain and investigate any potential correlation that may exist between serum 25(OH)D and urinary incontinence in senior males. Ultimately, a sum of 4663 elderly men were involved in our analysis. The outcomes of the univariable analysis illustrated that the group with vitamin D deficiency exhibited augmented odds of all three urinary incontinence types in comparison to the vitamin D-sufficient group. After accounting for age, race, and BMI, no appreciable variations in the outcomes were noticed. However, after accounting for all covariates, only SUI (OR = 1.677; 95% confidence interval (CI) = 1.074-2.618) and MUI (OR = 1.815; 95% confidence interval (CI) = 1.010-3.260) demonstrated statistical significance. Decreased serum 25(OH)D levels were connected with stress urinary incontinence and mixed urinary incontinence in elderly men.
Sections du résumé
Background
The correlation between serum 25-hydroxyvitamin D (25(OH)D) and different sub-types of urinary incontinence in elderly men continues to be uncertain. Hence, we performed this research to evaluate whether serum 25(OH)D levels are correlated with urinary incontinence among elderly men.
Methods
The present study incorporated the male population aged 50 years and above from four cycles of the NHANES database spanning from 2007 to 2014, for the purpose of analysis. The assessment of urinary incontinence was carried out through a correlation questionnaire, while standardized liquid chromatography-tandem mass spectrometry (LC-MS/MS) was adopted to quantify serum 25(OH)D. A weighted multi-factorial logistic regression analysis was carried out to ascertain and investigate any potential correlation that may exist between serum 25(OH)D and urinary incontinence in senior males.
Results
Ultimately, a sum of 4663 elderly men were involved in our analysis. The outcomes of the univariable analysis illustrated that the group with vitamin D deficiency exhibited augmented odds of all three urinary incontinence types in comparison to the vitamin D-sufficient group. After accounting for age, race, and BMI, no appreciable variations in the outcomes were noticed. However, after accounting for all covariates, only SUI (OR = 1.677; 95% confidence interval (CI) = 1.074-2.618) and MUI (OR = 1.815; 95% confidence interval (CI) = 1.010-3.260) demonstrated statistical significance.
Conclusion
Decreased serum 25(OH)D levels were connected with stress urinary incontinence and mixed urinary incontinence in elderly men.
Identifiants
pubmed: 37745700
doi: 10.3389/fendo.2023.1215666
pmc: PMC10515204
doi:
Substances chimiques
25-hydroxyvitamin D
A288AR3C9H
Vitamin D
1406-16-2
Calcifediol
P6YZ13C99Q
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1215666Informations de copyright
Copyright © 2023 Liu, Xu, Zhou, Hao, Chen and Liu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Age Ageing. 2014 Sep;43(5):589-91
pubmed: 25074537
Diabetes Metab Res Rev. 2022 Mar;38(3):e3499
pubmed: 34590783
Exp Mol Pathol. 2015 Apr;98(2):240-5
pubmed: 25681066
J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30
pubmed: 21646368
Expert Rev Anti Infect Ther. 2010 Dec;8(12):1359-69
pubmed: 21133662
Br J Psychiatry. 2013 Feb;202:100-7
pubmed: 23377209
Clin Nutr. 2019 Oct;38(5):2065-2070
pubmed: 30316534
J Urol. 2013 Aug;190(2):608-14
pubmed: 23399651
Eur Urol. 2022 Oct;82(4):387-398
pubmed: 35697561
J Bone Miner Res. 2022 Jan;37(1):121-136
pubmed: 34490953
Am J Obstet Gynecol. 2022 Apr;226(4):535.e1-535.e12
pubmed: 34678177
Int Urogynecol J. 2022 May;33(5):1083-1090
pubmed: 34491371
CNS Neurol Disord Drug Targets. 2019;18(6):496-501
pubmed: 31269890
J Urol. 2021 Jun;205(6):1584-1594
pubmed: 33207134
Ann Intern Med. 2020 Feb 4;172(3):ITC17-ITC32
pubmed: 32016335
Endocr Rev. 2019 Aug 1;40(4):1109-1151
pubmed: 30321335
Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):657-69
pubmed: 21872806
J Neuroinflammation. 2015 Aug 12;12:147
pubmed: 26259787
BMC Med. 2022 Sep 21;20(1):308
pubmed: 36127705
JAMA. 2017 Oct 24;318(16):1592-1604
pubmed: 29067433
Ann N Y Acad Sci. 2010 Apr;1193:146-52
pubmed: 20398021
Gynecol Endocrinol. 2019 Feb;35(2):155-159
pubmed: 30324854
Proc Nutr Soc. 2017 Aug;76(3):392-399
pubmed: 28347378
Minerva Obstet Gynecol. 2021 Apr;73(2):140-144
pubmed: 33103408
Int Urogynecol J. 2012 Nov;23(11):1517-26
pubmed: 22415704
Clin Nutr. 2021 May;40(5):2946-2957
pubmed: 33397599
Urology. 2011 Dec;78(6):1292-7
pubmed: 22014969
Nutr Res Rev. 2019 Dec;32(2):192-204
pubmed: 31203824
J Endocrinol Invest. 2010 Nov;33(10):730-8
pubmed: 20386089
Nat Rev Endocrinol. 2020 Apr;16(4):234-252
pubmed: 32029884
BMC Womens Health. 2022 Nov 4;22(1):431
pubmed: 36333692