Cancer hygiene hypothesis: A test from wild captive mammals.
animal care
biodiversity
captivity
neoplasm
pathogen
treatment
Journal
Ecology and evolution
ISSN: 2045-7758
Titre abrégé: Ecol Evol
Pays: England
ID NLM: 101566408
Informations de publication
Date de publication:
Sep 2023
Sep 2023
Historique:
received:
20
07
2023
revised:
31
08
2023
accepted:
04
09
2023
medline:
25
9
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
epublish
Résumé
The hygiene hypothesis, according to which the recent reduction of exposure to infectious agents in the human species would be the origin of various diseases, including autoimmune diseases and cancer, has often been proposed but not properly tested on animals. Here, we evaluated the relevance of this hypothesis to cancer risk in mammals in an original way, namely by using information on zoo mammals. We predicted that a higher richness of parasitic cohorts in the species' natural habitat would result in a greater occurrence of evolutionary mismatch due to the reduction of parasites in captive conditions. This, in turn, could contribute to an increased risk of developing lethal cancers. Using a comparative analysis of 112 mammalian species, we explored the potential relationship between cancer risk and parasite species richness using generalized phylogenetic least squares regressions to relate parasite species richness to cancer risk data. We found no strong evidence that parasite species richness increased cancer risk in zoo mammals for any of the parasite groups we tested. Without constituting definitive proof of the irrelevance of the hygienic hypothesis, our comparative study using zoo mammals does not support it, at least with respect to cancer risks.
Identifiants
pubmed: 37745791
doi: 10.1002/ece3.10547
pii: ECE310547
pmc: PMC10515881
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10547Informations de copyright
© 2023 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Ecol Evol. 2014 Jul;4(14):2913-30
pubmed: 25165528
Science. 2016 Nov 4;354(6312):618-622
pubmed: 27811275
Vet J. 2016 Jun;212:48-57
pubmed: 27256025
Sci Total Environ. 2021 Apr 1;763:142955
pubmed: 33109371
J Med Primatol. 2019 Feb;48(1):22-31
pubmed: 30370934
Evol Med Public Health. 2014 Nov 10;2015(1):52-74
pubmed: 25389105
Metabolism. 2019 Mar;92:121-135
pubmed: 30445141
Vet Microbiol. 2009 Jul 2;138(1-2):20-6
pubmed: 19264429
Clin Cancer Res. 2013 Jun 1;19(11):2834-41
pubmed: 23536438
Parasitology. 2008 Nov;135(13):1545-60
pubmed: 18070368
J Invertebr Pathol. 2015 Oct;131:83-106
pubmed: 26146225
Proc Biol Sci. 2023 Jun 28;290(2001):20230940
pubmed: 37357861
Ecology. 2011 Jan;92(1):3-10
pubmed: 21560670
Curr Aging Sci. 2012 Dec;5(3):170-7
pubmed: 23237593
Int J Obes Relat Metab Disord. 2004 Nov;28 Suppl 3:S2-9
pubmed: 15543214
PLoS Biol. 2019 Dec 4;17(12):e3000494
pubmed: 31800571
Vet Parasitol. 2008 Oct 20;157(1-2):154-9
pubmed: 18723289
Evol Appl. 2016 Dec 26;10(3):215-225
pubmed: 28250806
Annu Rev Entomol. 2011;56:123-42
pubmed: 20731604
Gut. 2005 Jan;54(1):87-90
pubmed: 15591509
Front Immunol. 2021 Mar 16;12:635935
pubmed: 33796103
Nat Rev Cancer. 2018 Aug;18(8):471-484
pubmed: 29784935
Cancer Res. 1982 Sep;42(9):3741-6
pubmed: 7105040
J Neuroimmunol. 2011 Apr;233(1-2):3-5
pubmed: 21295861
Front Immunol. 2021 Mar 18;12:637087
pubmed: 33815389
Nat Rev Immunol. 2018 Feb;18(2):105-120
pubmed: 29034905
Am J Hum Genet. 1962 Dec;14:353-62
pubmed: 13937884
Pathogens. 2021 Oct 08;10(10):
pubmed: 34684244
Evol Appl. 2013 Jan;6(1):144-59
pubmed: 23396885
Evol Appl. 2012 Jun;5(4):368-79
pubmed: 25568057
Cancer Med. 2018 Jun;7(6):2665-2681
pubmed: 29663688
Ecohealth. 2009 Sep;6(3):414-25
pubmed: 19898897
Nature. 2022 Jan;601(7892):263-267
pubmed: 34937938
Bioinformatics. 2019 Feb 1;35(3):526-528
pubmed: 30016406
Evol Appl. 2020 Mar 23;13(7):1719-1732
pubmed: 32821279
Vet World. 2016 Jun;9(6):540-3
pubmed: 27397973
Ecology. 2017 May;98(5):1476
pubmed: 28273333
BMJ. 1989 Nov 18;299(6710):1259-60
pubmed: 2513902
Nature. 1976 Jun 10;261(5560):506-8
pubmed: 59315
Proc Biol Sci. 2012 Nov 7;279(1746):4305-21
pubmed: 22933370
Trends Cancer. 2015 Nov 1;1(3):174-182
pubmed: 26618199
Eur J Cancer. 2007 Nov;43(16):2396-403
pubmed: 17826085
Evol Med Public Health. 2013 Jan;2013(1):89-103
pubmed: 24481190
Parasite. 2022;29:43
pubmed: 36125313
Evol Appl. 2021 Feb 08;14(4):877-892
pubmed: 33897809
Nat Rev Cancer. 2006 Mar;6(3):193-203
pubmed: 16467884
Br J Cancer. 2008 Nov 4;99(9):1529-33
pubmed: 18827817
Am J Gastroenterol. 2003 Sep;98(9):2034-41
pubmed: 14499784
Sci Total Environ. 1990 May 1;94(1-2):33-50
pubmed: 2360038
Radiol Oncol. 2021 Jan 12;55(1):7-17
pubmed: 33885236