Boston Birth Cohort profile: rationale and study design.
Boston Birth Cohort
Early life origins of chronic diseases
Environment
Genetics
Longitudinal study
Journal
Precision nutrition
ISSN: 2563-9021
Titre abrégé: Precis Nutr
Pays: Canada
ID NLM: 9918419162506676
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
09
05
2022
revised:
09
06
2022
accepted:
16
06
2022
medline:
18
8
2022
pubmed:
18
8
2022
entrez:
25
9
2023
Statut:
epublish
Résumé
In1998, the Boston Birth Cohort (BBC) was initiated at Boston Medical Center (BMC) in response to persistently high rates of preterm birth (PTB, defined as birth before 37 weeks of gestation) in the US population and the longstanding profound PTB disparity among Black, Indigenous, and people of color (BIPOC). The BBC encompasses two linked study protocols: The PTB Study serves as the baseline recruitment in the BBC. It aims to address fundamental questions about the causes and consequences of PTB. The study oversamples preterm babies using a case/control study design, in which cases are defined as mothers who deliver a preterm and/or low birthweight baby (<2500 grams regardless of gestational age). Controls are enrolled at a 2:1 control/case ratio and matched by maternal age (±5 years), self-reported race and ethnicity, and date of delivery (± 7 days for case delivery). From inception, it was designed as a comprehensive gene-environmental study of PTB. As a natural extension, the Children's Health Study, under a separate but linked Institutional Review Board protocol, is a longitudinal follow-up study of the participants who were recruited at birth in the PTB Study and who continue pediatric care at BMC. This linked model allows for investigation of early life origins of pediatric and chronic disease in a prospective cohort design. The BBC is one of the largest and longest National Institutes of Health-funded prospective birth cohort studies in the United States, consisting of 8733 mother-child dyads enrolled in the PTB Study at birth, and of those, 3592 children have been enrolled in the Children's Health Study, with a median follow-up of 14.5 years. The BBC mirrors the urban, underresourced, and underrepresented BIPOC population served by BMC. A high proportion of BBC children were born prematurely and had chronic health conditions (e.g., asthma, obesity, and elevated blood pressure) in childhood. The BBC's long-term goal has been to build a large, comprehensive database (epidemiological, clinical, and multiomics) and biospecimen repository to elucidate early life origins of pediatric and chronic diseases and identify modifiable upstream factors (e.g., psychosocial, environmental, and nutritional) to improve health across the life course for BIPOC mothers and children.
Identifiants
pubmed: 37745944
doi: 10.1097/PN9.0000000000000011
pmc: PMC9844822
mid: NIHMS1818381
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e00011Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES031521
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD098232
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES031272
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD041702
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD086013
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s), Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
None declared.
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