Impact of tacrolimus intra-patient variability in adverse outcomes after organ transplantation.
Graft survival
Intra-patient variability
Organ transplantation
Outcomes
Rejection
Tacrolimus
Journal
World journal of transplantation
ISSN: 2220-3230
Titre abrégé: World J Transplant
Pays: United States
ID NLM: 101608356
Informations de publication
Date de publication:
18 Sep 2023
18 Sep 2023
Historique:
received:
28
06
2023
revised:
31
07
2023
accepted:
11
08
2023
medline:
25
9
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
ppublish
Résumé
Tacrolimus (Tac) is currently the most common calcineurin-inhibitor employed in solid organ transplantation. High intra-patient variability (IPV) of Tac (Tac IPV) has been associated with an increased risk of immune-mediated rejection and poor outcomes after kidney transplantation. Few data are available concerning the impact of high Tac IPV in non-kidney transplants. However, even in kidney transplantation, there is still a controversy whether high Tac IPV is indeed detrimental in respect to graft and/or patient survival. This may be due to different methods employed to evaluate IPV and distinct time frames adopted to assess graft and patient survival in those reports published up to now in the literature. Little is also known about the influence of high Tac IPV in the development of other untoward adverse events, update of the current knowledge regarding the impact of Tac IPV in different outcomes following kidney, liver, heart, lung, and pancreas tran splantation to better evaluate its use in clinical practice.
Identifiants
pubmed: 37746041
doi: 10.5500/wjt.v13.i5.254
pmc: PMC10514747
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
254-263Informations de copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Références
Am J Transplant. 2019 May;19(5):1410-1420
pubmed: 30506623
Transpl Int. 2020 Dec;33(12):1681-1692
pubmed: 32881096
Pharmaceutics. 2022 Feb 08;14(2):
pubmed: 35214111
Clin Pharmacol Ther. 2020 Feb;107(2):347-358
pubmed: 31449663
J Nephrol. 2016 Apr;29(2):269-276
pubmed: 26374111
Front Pharmacol. 2022 Oct 13;13:973564
pubmed: 36313323
Pharmaceuticals (Basel). 2022 Dec 09;15(12):
pubmed: 36558980
Pharmacotherapy. 2021 Jan;41(1):103-118
pubmed: 33131078
Clin Transl Sci. 2022 Jun;15(6):1544-1555
pubmed: 35373449
Transplantation. 2017 Dec;101(12):2931-2938
pubmed: 28658199
J Clin Pharmacol. 2019 Mar;59(3):309-325
pubmed: 30371942
Pharmaceutics. 2021 Nov 20;13(11):
pubmed: 34834385
J Heart Lung Transplant. 2015 Nov;34(11):1442-8
pubmed: 26186804
PLoS One. 2018 May 10;13(5):e0196552
pubmed: 29746495
Transplant Rev (Orlando). 2015 Apr;29(2):78-84
pubmed: 25687818
Transplant Direct. 2017 Jul 07;3(8):e192
pubmed: 28795143
J Pharm Health Care Sci. 2022 Oct 1;8(1):25
pubmed: 36180948
Eur J Clin Pharmacol. 2019 Jul;75(7):951-958
pubmed: 30762079
J Clin Med. 2022 Oct 26;11(21):
pubmed: 36362548
Transplantation. 2018 Mar;102(3):e108-e114
pubmed: 29315140
Can J Kidney Health Dis. 2021 Jun 15;8:20543581211021742
pubmed: 34188946
Eur J Drug Metab Pharmacokinet. 2020 Dec;45(6):749-760
pubmed: 32886348
Pediatr Transplant. 2021 Nov;25(7):e14043
pubmed: 34390091
Front Immunol. 2019 Dec 20;10:2912
pubmed: 31921171
Am J Transplant. 2020 Aug;20(8):1969-1983
pubmed: 32406604
Clin Transplant. 2018 Dec;32(12):e13424
pubmed: 30318646
Br J Clin Pharmacol. 2015 Oct;80(4):630-41
pubmed: 25846845
Sci Rep. 2021 Mar 8;11(1):5397
pubmed: 33686160
Transplantation. 2019 Nov;103(11):2329-2337
pubmed: 30801539
Am J Transplant. 2016 Oct;16(10):2954-2963
pubmed: 27013142
Br J Clin Pharmacol. 2022 Jan;88(1):75-83
pubmed: 33899267
Transplantation. 2017 Feb;101(2):430-436
pubmed: 26950724
Ther Drug Monit. 2012 Dec;34(6):680-5
pubmed: 23149441
Transplantation. 2020 Apr;104(4):881-887
pubmed: 32224815
Dig Dis Sci. 2013 Mar;58(3):824-34
pubmed: 23053889
Nephrol Dial Transplant. 2017 Feb 1;32(2):393-399
pubmed: 28025383
Exp Clin Transplant. 2018 Jun;16(3):326-332
pubmed: 28969528
Pediatr Transplant. 2017 Dec;21(8):
pubmed: 29034612
Nephrol Dial Transplant. 2010 Aug;25(8):2757-63
pubmed: 20190242
Sci Rep. 2021 Jun 9;11(1):12114
pubmed: 34108576
Am J Transplant. 2018 Oct;18(10):2571-2578
pubmed: 29989311
Transpl Int. 2016 Nov;29(11):1158-1167
pubmed: 27188932
Sci Rep. 2022 Sep 28;12(1):16169
pubmed: 36171260
Am J Transplant. 2019 Oct;19(10):2805-2813
pubmed: 30859672
Rev Esp Cardiol (Engl Ed). 2022 Feb;75(2):129-140
pubmed: 33744197
Thromb Haemost. 1993 Mar 1;69(3):236-9
pubmed: 8470047
Clin Pharmacokinet. 2004;43(10):623-53
pubmed: 15244495
Eur J Clin Pharmacol. 2021 Jan;77(1):63-69
pubmed: 32803287
Ther Drug Monit. 2020 Oct;42(5):702-709
pubmed: 32941396
Am J Transplant. 2018 Jun;18(6):1527-1533
pubmed: 29513387
Liver Transpl. 2014 Oct;20(10):1168-77
pubmed: 24931127
Pediatr Transplant. 2010 Dec;14(8):968-75
pubmed: 21040278
Pediatr Nephrol. 2022 Oct;37(10):2503-2514
pubmed: 35166920
Am J Transplant. 2017 Oct;17(10):2668-2678
pubmed: 28321975
Pharmaceutics. 2022 Aug 23;14(9):
pubmed: 36145503
Pharmacotherapy. 2019 May;39(5):609-613
pubmed: 30892740
Pediatr Transplant. 2010 Dec;14(8):940-3
pubmed: 20887400
Front Immunol. 2021 Sep 30;12:746013
pubmed: 34659243
Pediatr Transplant. 2019 May;23(3):e13388
pubmed: 30916883
Pediatr Nephrol. 2016 Dec;31(12):2345-2352
pubmed: 27286686
Am J Surg. 2020 Apr;219(4):583-586
pubmed: 32122660
Pediatr Transplant. 2008 Feb;12(1):67-72
pubmed: 18186891
Pediatr Transplant. 2008 May;12(3):284-8
pubmed: 18331387
Kidney Int. 2014 Jun;85(6):1404-11
pubmed: 24336032
Transplantation. 2016 Nov;100(11):2479-2485
pubmed: 26703349
Transplant Direct. 2019 May 22;5(6):e455
pubmed: 31321291
J Clin Med. 2020 Jun 19;9(6):
pubmed: 32575525
World J Gastroenterol. 2018 Apr 28;24(16):1795-1802
pubmed: 29713132
Transplantation. 2021 Mar 1;105(3):484-495
pubmed: 32541562
Clin Pharmacokinet. 2019 May;58(5):593-613
pubmed: 30415459