Hemoglobin, albumin, lymphocyte, and platelet score as a predictor of prognosis in metastatic gastric cancer.
Biomarker
Gastric cancer
Hemoglobin, albumin, lymphocyte, and platelet score
Nutritional index
Prognosis
Survival
Journal
World journal of gastrointestinal oncology
ISSN: 1948-5204
Titre abrégé: World J Gastrointest Oncol
Pays: China
ID NLM: 101532470
Informations de publication
Date de publication:
15 Sep 2023
15 Sep 2023
Historique:
received:
26
04
2023
revised:
17
06
2023
accepted:
29
07
2023
medline:
25
9
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
ppublish
Résumé
The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, derived from a composite evaluation of markers reflecting the tumor-inflammation relationship and nutritional status, has been substantiated as a noteworthy prognostic determinant for diverse malignancies. To investigate how the HALP score relates to prognosis in patients with metastatic gastric cancer. The cutoff values for the HALP score, neutrophil/lymphocyte ratio, and platelet/lymphocyte ratio were determined using receiver operating characteristic analysis. Low HALP scores were defined as those less than 24.79 and high HALP scores as those greater than 24.79. The study cohort comprised 147 patients and 110 of them (74.8%) were male. The patients' median age was 63 (22-89) years. The median overall survival was significantly superior in the patients with high HALP scores than in those with low HALP scores (10.4 mo The HALP score was found to be a prognostic factor in patients with metastatic gastric cancer.
Sections du résumé
BACKGROUND
BACKGROUND
The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, derived from a composite evaluation of markers reflecting the tumor-inflammation relationship and nutritional status, has been substantiated as a noteworthy prognostic determinant for diverse malignancies.
AIM
OBJECTIVE
To investigate how the HALP score relates to prognosis in patients with metastatic gastric cancer.
METHODS
METHODS
The cutoff values for the HALP score, neutrophil/lymphocyte ratio, and platelet/lymphocyte ratio were determined using receiver operating characteristic analysis. Low HALP scores were defined as those less than 24.79 and high HALP scores as those greater than 24.79.
RESULTS
RESULTS
The study cohort comprised 147 patients and 110 of them (74.8%) were male. The patients' median age was 63 (22-89) years. The median overall survival was significantly superior in the patients with high HALP scores than in those with low HALP scores (10.4 mo
CONCLUSION
CONCLUSIONS
The HALP score was found to be a prognostic factor in patients with metastatic gastric cancer.
Identifiants
pubmed: 37746652
doi: 10.4251/wjgo.v15.i9.1626
pmc: PMC10514725
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1626-1635Informations de copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors declare no conflict of interest.
Références
Mol Cell Pediatr. 2018 Apr 3;5(1):5
pubmed: 29616417
Lancet Gastroenterol Hepatol. 2020 Jan;5(1):42-54
pubmed: 31648970
Gastric Cancer. 2017 Mar;20(2):217-225
pubmed: 26897166
Am J Med. 2004 Apr 5;116 Suppl 7A:11S-26S
pubmed: 15050883
Oncotarget. 2015 Dec 1;6(38):41370-82
pubmed: 26497995
World J Surg. 2010 Oct;34(10):2393-8
pubmed: 20602101
J Gastrointest Cancer. 2019 Dec;50(4):763-768
pubmed: 30058031
Int J Clin Exp Med. 2015 Apr 15;8(4):5937-42
pubmed: 26131188
Ann Surg. 2005 Jan;241(1):27-39
pubmed: 15621988
Oncotarget. 2016 Nov 1;7(44):72076-72083
pubmed: 27765916
Carcinogenesis. 2009 Jul;30(7):1073-81
pubmed: 19468060
Anticancer Res. 2008 May-Jun;28(3B):1947-50
pubmed: 18630486
Front Oncol. 2022 Aug 30;12:936206
pubmed: 36110962
Sci Rep. 2018 Jan 15;8(1):794
pubmed: 29335609
J Gastrointest Oncol. 2021 Dec;12(6):2706-2718
pubmed: 35070400
J Coll Physicians Surg Pak. 2022 Sep;32(9):1154-1159
pubmed: 36089712
Oncol Lett. 2016 May;11(5):2959-2964
pubmed: 27123046
World J Surg Oncol. 2020 Jul 30;18(1):191
pubmed: 32731872