Oxidative stress signaling in the pathogenesis of diabetic cardiomyopathy and the potential therapeutic role of antioxidant naringenin.
Diabetic cardiomyopathy
NF-κB
NOX
Nrf2
REAGE
naringenin
oxidative stress
signal pathways
Journal
Redox report : communications in free radical research
ISSN: 1743-2928
Titre abrégé: Redox Rep
Pays: England
ID NLM: 9511366
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
medline:
26
9
2023
pubmed:
25
9
2023
entrez:
25
9
2023
Statut:
ppublish
Résumé
Diabetes mellitus (DM) is one of the most prevalent metabolic disorders that poses a global threat to human health. It can lead to complications in multiple organs and tissues, owing to its wide-ranging impact on the human body. Diabetic cardiomyopathy (DCM) is a specific cardiac manifestation of DM, which is characterized by heart failure in the absence of coronary heart disease, hypertension and valvular heart disease. Given that oxidative stress is a key factor in the pathogenesis of DCM, intervening to mitigate oxidative stress may serve as a therapeutic strategy for managing DCM. Naringenin is a natural product with anti-oxidative stress properties that can suppress oxidative damage by regulating various oxidative stress signaling pathways. In this review, we address the relationship between oxidative stress and its primary signaling pathways implicated in DCM, and explores the therapeutic potential of naringenin in DCM.
Identifiants
pubmed: 37747066
doi: 10.1080/13510002.2023.2246720
pmc: PMC10538464
doi:
Substances chimiques
Antioxidants
0
naringenin
HN5425SBF2
Flavanones
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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