Prebiotic Synthesis of 3',5'-Cyclic Adenosine and Guanosine Monophosphates through Carbodiimide-Assisted Cyclization.

RNA cyclization formamide nucleotides prebiotic chemistry

Journal

Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360

Informations de publication

Date de publication:
25 Sep 2023
Historique:
revised: 25 09 2023
received: 14 07 2023
pubmed: 25 9 2023
medline: 25 9 2023
entrez: 25 9 2023
Statut: aheadofprint

Résumé

3',5'-Cyclic nucleotides play a fundamental role in modern biochemical processes and have been suggested to have played a central role at the origin of terrestrial life. In this work, we suggest that a formamide-based systems chemistry might account for their availability on the early Earth. In particular, we demonstrate that in a liquid formamide environment at elevated temperatures 3',5'-cyclic nucleotides are obtained in good yield and selectivity upon intramolecular cyclization of 5'-phosphorylated nucleosides in the presence of carbodiimides.

Identifiants

pubmed: 37747702
doi: 10.1002/cbic.202300510
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202300510

Subventions

Organisme : Czech Science Foundation
ID : 22-25057S
Organisme : Czech Science Foundation
ID : CZ.02.01.01/00/22_008/0004587
Organisme : Ministry of Education, Youth and Sports (Czech Republic)

Informations de copyright

© 2023 Wiley-VCH GmbH.

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Auteurs

Rémi Coulon (R)

CATRIN - Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc, Šlechtitelů 27, 77900, Olomouc, Czech Republic.
Department of Physical Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 77146, Olomouc, Czech Republic.
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 61200, Brno, Czech Republic.

Barbora Papoušková (B)

CATRIN - Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc, Šlechtitelů 27, 77900, Olomouc, Czech Republic.
Department of Analytical Chemistry, Faculty of Science, Palacký University Olomouc, 17. listopadu 12, 77146, Olomouc, Czech Republic.

Elmira Mohammadi (E)

CATRIN - Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc, Šlechtitelů 27, 77900, Olomouc, Czech Republic.
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, V6T 1Z1, BC, Canada.

Michal Otyepka (M)

CATRIN - Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc, Šlechtitelů 27, 77900, Olomouc, Czech Republic.
IT4Innovations, VSB - Technical University of Ostrava, 17. listopadu 2172/15, 708 00, Ostrava, Poruba, Czech Republic.

Sreekar Wunnava (S)

Department of Physics, NanoSystems Initiative Munich and Center for Nanoscience, Ludwig-Maximilians-Universität München, Amalienstrasse 54, 80799, Munich, Germany.

Jiří Šponer (J)

CATRIN - Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc, Šlechtitelů 27, 77900, Olomouc, Czech Republic.
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 61200, Brno, Czech Republic.

Judit E Šponer (JE)

CATRIN - Regional Centre of Advanced Technologies and Materials, Palacký University Olomouc, Šlechtitelů 27, 77900, Olomouc, Czech Republic.
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 61200, Brno, Czech Republic.

Classifications MeSH