KCNQ potassium channels modulate Wnt activity in gastro-oesophageal adenocarcinomas.

Humans KCNQ Potassium Channels / genetics KCNQ3 Potassium Channel / genetics KCNQ2 Potassium Channel / physiology Adenocarcinoma / genetics

Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
12 2023
Historique:
received: 28 04 2023
revised: 11 09 2023
accepted: 11 09 2023
medline: 4 10 2023
pubmed: 26 9 2023
entrez: 25 9 2023
Statut: epublish

Résumé

Voltage-sensitive potassium channels play an important role in controlling membrane potential and ionic homeostasis in the gut and have been implicated in gastrointestinal (GI) cancers. Through large-scale analysis of 897 patients with gastro-oesophageal adenocarcinomas (GOAs) coupled with in vitro models, we find

Identifiants

DOI: 10.26508/lsa.202302124 PMID: 37748809 PMC: PMC10520261
pubmed: 37748809
pii: 6/12/e202302124
doi: 10.26508/lsa.202302124
pmc: PMC10520261
pii:
doi:

Substances chimiques

KCNQ Potassium Channels 0
KCNQ3 Potassium Channel 0
KCNQ2 Potassium Channel 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MR/S000216/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S000216/2
Pays : United Kingdom

Informations de copyright

© 2023 Shorthouse et al.

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Auteurs

David Shorthouse (D)

https://ror.org/02jx3x895 Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, University College London, London, UK d.shorthouse@ucl.ac.uk.
ORCID: 0000-0002-3207-3584

Lizhe Zhuang (L)

Institute for Early Detection, CRUK Cambridge Centre, Cambridge, UK.

Eric P Rahrmann (EP)

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-2369-0342

Cassandra Kosmidou (C)

Institute for Early Detection, CRUK Cambridge Centre, Cambridge, UK.

Katherine Wickham Rahrmann (K)

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.
ORCID: 0009-0004-7564-9987

Michael Hall (M)

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.

Benedict Greenwood (B)

https://ror.org/02jx3x895 Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, University College London, London, UK.

Ginny Devonshire (G)

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.

Richard J Gilbertson (RJ)

Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK.

Rebecca C Fitzgerald (RC)

Institute for Early Detection, CRUK Cambridge Centre, Cambridge, UK.

Benjamin A Hall (BA)

https://ror.org/02jx3x895 Department of Medical Physics and Biomedical Engineering, Malet Place Engineering Building, University College London, London, UK b.hall@ucl.ac.uk.
ORCID: 0000-0003-0355-2946

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › KCNQ potassium channels modulate Wnt activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques rectifiants retardés › Canaux potassiques KNCQ › KCNQ potassium channels modulate Wnt activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques rectifiants retardés › Canaux potassiques KNCQ › Canal potassique KCNQ3 › KCNQ potassium channels modulate Wnt activity...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques rectifiants retardés › Canaux potassiques KNCQ › Canal potassique KCNQ2 › KCNQ potassium channels modulate Wnt activity...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › KCNQ potassium channels modulate Wnt activity...