Functional diversity of c-di-GMP receptors in prokaryotic and eukaryotic systems.
Bacteria
Binding affinity
Eukaryotes
Evolutionary relatedness
Interspecies
Receptor
c-di-GMP
Journal
Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464
Informations de publication
Date de publication:
25 09 2023
25 09 2023
Historique:
received:
21
06
2023
accepted:
09
08
2023
medline:
27
9
2023
pubmed:
26
9
2023
entrez:
25
9
2023
Statut:
epublish
Résumé
Cyclic bis-(3', 5')-dimeric guanosine monophosphate (c-di-GMP) is ubiquitous in many bacterial species, where it functions as a nucleotide-based secondary messenger and is a vital regulator of numerous biological processes. Due to its ubiquity, most bacterial species possess a wide range of downstream receptors that has a binding affinity to c-di-GMP and elicit output responses. In eukaryotes, several enzymes and riboswitches operate as receptors that interact with c-di-GMP and transduce cellular or environmental signals. This review examines the functional variety of receptors in prokaryotic and eukaryotic systems that exhibit distinct biological responses after interacting with c-di-GMP. Evolutionary relationships and similarities in distance among the c-di-GMP receptors in various bacterial species were evaluated to understand their specificities. Furthermore, residues of receptors involved in c-di-GMP binding are summarized. This review facilitates the understanding of how distinct receptors from different origins bind c-di-GMP equally well, yet fulfill diverse biological roles at the interspecies, intraspecies, and interkingdom levels. Furthermore, it also highlights c-di-GMP receptors as potential therapeutic targets, particularly those found in pathogenic microorganisms. Video Abstract.
Identifiants
pubmed: 37749602
doi: 10.1186/s12964-023-01263-5
pii: 10.1186/s12964-023-01263-5
pmc: PMC10519070
doi:
Substances chimiques
bis(3',5')-cyclic diguanylic acid
61093-23-0
Cyclic GMP
H2D2X058MU
Polymers
0
Types de publication
Video-Audio Media
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
259Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
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