The Bacteroidetes Q-rule and glutaminyl cyclase activity increase the stability of extracytoplasmic proteins.
Porphyromonas gingivalis
essential protein
periodontitis
posttranslational modification
proteolysis
pyroglutamyl formation
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
26 Sep 2023
26 Sep 2023
Historique:
medline:
26
9
2023
pubmed:
26
9
2023
entrez:
26
9
2023
Statut:
aheadofprint
Résumé
In Gram-negative didermal species of the phylum Bacteroidetes, the majority of pre(pro)proteins exported across the cell membrane via the Sec system follow the Q-rule: a glutamine residue immediately downstream of a leader peptide is exposed as the new amino terminus by type I signal peptidases and converted to a pyroglutamate (also called oxyproline) residue by an inner membrane-associated glutaminyl cyclase (QC). Here, we show that the QC from
Identifiants
pubmed: 37750700
doi: 10.1128/mbio.00980-23
pmc: PMC10653852
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0098023Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE022597
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE030939
Pays : United States
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