International Liver Transplantation Society Global Census: First Look at Pediatric Liver Transplantation Activity Around the World.
Journal
Transplantation
ISSN: 1534-6080
Titre abrégé: Transplantation
Pays: United States
ID NLM: 0132144
Informations de publication
Date de publication:
01 10 2023
01 10 2023
Historique:
medline:
23
10
2023
pubmed:
26
9
2023
entrez:
26
9
2023
Statut:
ppublish
Résumé
Over 16 000 children under the age of 15 died worldwide in 2017 because of liver disease. Pediatric liver transplantation (PLT) is currently the standard of care for these patients. The aim of this study is to describe global PLT activity and identify variations between regions. A survey was conducted from May 2018 to August 2019 to determine the current state of PLT. Transplant centers were categorized into quintile categories according to the year they performed their first PLT. Countries were classified according to gross national income per capita. One hundred eight programs from 38 countries were included (68% response rate). 10 619 PLTs were performed within the last 5 y. High-income countries performed 4992 (46.4%) PLT, followed by upper-middle- (4704 [44·3%]) and lower-middle (993 [9·4%])-income countries. The most frequently used type of grafts worldwide are living donor grafts. A higher proportion of lower-middle-income countries (68·7%) performed ≥25 living donor liver transplants over the last 5 y compared to high-income countries (36%; P = 0.019). A greater proportion of programs from high-income countries have performed ≥25 whole liver transplants (52.4% versus 6.2%; P = 0.001) and ≥25 split/reduced liver transplants (53.2% versus 6.2%; P < 0.001) compared to lower-middle-income countries. This study represents, to our knowledge, the most geographically comprehensive report on PLT activity and a first step toward global collaboration and data sharing for the greater good of children with liver disease; it is imperative that these centers share the lead in PLT.
Sections du résumé
BACKGROUND
Over 16 000 children under the age of 15 died worldwide in 2017 because of liver disease. Pediatric liver transplantation (PLT) is currently the standard of care for these patients. The aim of this study is to describe global PLT activity and identify variations between regions.
METHODS
A survey was conducted from May 2018 to August 2019 to determine the current state of PLT. Transplant centers were categorized into quintile categories according to the year they performed their first PLT. Countries were classified according to gross national income per capita.
RESULTS
One hundred eight programs from 38 countries were included (68% response rate). 10 619 PLTs were performed within the last 5 y. High-income countries performed 4992 (46.4%) PLT, followed by upper-middle- (4704 [44·3%]) and lower-middle (993 [9·4%])-income countries. The most frequently used type of grafts worldwide are living donor grafts. A higher proportion of lower-middle-income countries (68·7%) performed ≥25 living donor liver transplants over the last 5 y compared to high-income countries (36%; P = 0.019). A greater proportion of programs from high-income countries have performed ≥25 whole liver transplants (52.4% versus 6.2%; P = 0.001) and ≥25 split/reduced liver transplants (53.2% versus 6.2%; P < 0.001) compared to lower-middle-income countries.
CONCLUSIONS
This study represents, to our knowledge, the most geographically comprehensive report on PLT activity and a first step toward global collaboration and data sharing for the greater good of children with liver disease; it is imperative that these centers share the lead in PLT.
Identifiants
pubmed: 37750781
doi: 10.1097/TP.0000000000004644
pii: 00007890-202310000-00004
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2087-2097Investigateurs
Jean Botha
(J)
Naimish N Mehta
(NN)
Abu Bakar Hafeez Bhatti
(A)
Daniel Zamora-Valdes
(D)
None Anand
Riccardo Superina
(R)
Ruben de Kleine
(R)
Maria A Matamoros
(MA)
Tayana Bedregal-Mendoza
(T)
J Steve Bynon
(J)
Luis C Rodriguez-Sancho
(LC)
Alan Langnas
(A)
Anil Dhawan
(A)
Yasuhiro Ogura
(Y)
Rodrigo Vianna
(R)
Bibigul Ilyassova
(B)
Niramol Tantemsapya
(N)
Sarah Bellemare
(S)
Nadia Ovchinsky
(N)
Suryabhan Bhalerao
(S)
Deniz Balci
(D)
Marcelo Dip
(M)
Oscar Imventarza
(O)
Richard S Mangus
(RS)
Jonathan Fawcett
(J)
Teresa M Antonini
(TM)
Anurag Shrimal
(A)
Zhi-Jun Zhu
(ZJ)
Jairo Rivera
(J)
Murat Dayangac
(M)
John McCall
(J)
Melina Utz Melere
(M)
Michael Stormon
(M)
Koichi Mizuta
(K)
Wei Gao
(W)
Tri Hening Rahayatri
(T)
Alejandro Costaguta
(A)
Sergei Gautier
(S)
Kourosh Kazemi
(K)
Jorge Martinez-Castillo
(J)
Worapot Apinyachon
(W)
Mukul Rastogi
(M)
Juan C Restrepo
(JC)
Yagi Takahito
(Y)
Srinivasa Ravichandra
(S)
Anabel Vanin
(A)
Sandra Vieira
(S)
Carlos Luque
(C)
Gabriel Gondolesi
(G)
Koji Hashimoto
(K)
Nada Yazigi
(N)
Sylvie Lebel
(S)
Alisha Mavis
(A)
Ronen Arnon
(R)
Ricardo Chavez-Vargas
(R)
Scott Elisofon
(S)
Dev M Desai
(DM)
Hideaki Okajima
(H)
Srinath Chinnakotla
(S)
Evelyn Hsu
(E)
Jorge Reyes
(J)
Sergelen Orgoi
(S)
Vikram Raut
(V)
Seak Hee Oh
(S)
Pamela Valentino
(P)
Sukru Emre
(S)
Marco Spada
(M)
Dan Leung
(D)
Ramon Charco
(R)
Bo-Goran Ericzon
(BG)
Ryan Fischer
(R)
Juan V Del Rio-Martin
(JV)
Umberto Cillo
(U)
Hossam Soliman
(H)
Gustavo Varela-Fascinetto
(G)
Vanessa de Villa
(V)
Mehmet Haberal
(M)
Joshue Covarrubias
(J)
Michele Colledan
(M)
Jean de Ville de Goyet
(J)
Chirag Desai
(C)
Shikha Sundaram
(S)
Jiri Fronek
(J)
Satish N Nadig
(SN)
Vidyadhar P Mali
(VP)
Francesco Tandoi
(F)
Rohit Kohli
(R)
Neelam Mohan
(N)
Neerav Goyal
(N)
Drisya Santhosh
(D)
Dominique Debray
(D)
Ozlem Durmaz
(O)
Ruth De Bruyne
(R)
Piotr Kaliciński
(P)
Loreto Hierro
(L)
Robert Venick
(R)
Emily Perito
(E)
Yael Mozer-Glassberg
(Y)
Chao-Long Chen
(CL)
Elizabeth Rand
(E)
Saman Nikeghbalian
(S)
Deirdre Kelly
(D)
Olivier Boillot
(O)
Linda S Book
(LS)
Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no funding or conflicts of interest.
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